Literature summary for 2.3.2.12 extracted from

Chladek, S.; Bhuta, P.
Inhibition of the peptidyltransferase acceptor site by 2(3)-O-cycloleucyl- and alpha-aminoisobutyryl derivatives of cytidylyl-(3-5)adenosine (1982), Biochim. Biophys. Acta, 696, 212-217.

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Inhibitors

Inhibitors	Comment	Organism	Structure
cytidylyl(3'-5')2'(3')-O-(alpha-aminoisobutyryl)adenosine	-	Escherichia coli
cytidylyl(3'-5')2'(3')-O-cycloleucyladenosine	-	Escherichia coli

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
ribosome	70S ribosomes	Escherichia coli	5840	-

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	MRE-600	-
Escherichia coli MRE 600	-	MRE-600	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
AcPhe-tRNA + puromycin	AcPhe-tRNA-polyU-70S ribosome complex	Escherichia coli	tRNA + AcPhe-puromycin	-	?
AcPhe-tRNA + puromycin	AcPhe-tRNA-polyU-70S ribosome complex	Escherichia coli MRE 600	tRNA + AcPhe-puromycin	-	?

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Release 2023.1 (January 2023)