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Literature summary for 2.3.1.B43 extracted from

  • Wang, T.; Tan, G.; Jiang, M.; Liu, G.; Li, W.; Qing, X.
    SIRT5 inhibits glycolysis and nasal type extranodal NK/T cell lymphoma cell proliferation by catalyzing the desuccinylation of glucose-6-phosphate isomerase (2025), Transl. Oncol., 51, 102215.
    View publication on PubMed
Search for more literature for 2.3.1.B43

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[glucose-6-phosphate isomerase]-N6-succinyl-L-lysine + NAD+ + H2O Homo sapiens
-
 [glucose-6-phosphate isomerase]-L-lysine + 2''-O-succinyl-ADP-D-ribose + nicotinamide
-
 ?
[glucose-6-phosphate isomerase]-N6-succinyl-L-lysine + NAD+ + H2O Mus musculus
-
 [glucose-6-phosphate isomerase]-L-lysine + 2''-O-succinyl-ADP-D-ribose + nicotinamide
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NXA8
-
-
Mus musculus Q8K2C6
-
-

Source Tissue

Source Tissue Comment Organism Textmining
natural killer cell line
-
 Homo sapiens
-
natural killer cell line
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[glucose-6-phosphate isomerase]-N6-succinyl-L-lysine + NAD+ + H2O
-
 Homo sapiens [glucose-6-phosphate isomerase]-L-lysine + 2''-O-succinyl-ADP-D-ribose + nicotinamide
-
 ?
[glucose-6-phosphate isomerase]-N6-succinyl-L-lysine + NAD+ + H2O
-
 Mus musculus [glucose-6-phosphate isomerase]-L-lysine + 2''-O-succinyl-ADP-D-ribose + nicotinamide
-
 ?

Synonyms

Synonyms Comment Organism
SIRT5
-
 Homo sapiens
SIRT5
-
 Mus musculus

Expression

Organism Comment Expression
Homo sapiens downregulated in the extranodal natural killer/T-cell lymphoma down
Mus musculus downregulated in the extranodal natural killer/T-cell lymphoma down

General Information

General Information Comment Organism
drug target SIRT5 inhibits glycolysis via catalyzing the desuccinylation of glycolytic enzyme glucose-6-phosphate isomerase, thereby repressing extranodal natural killer/T-cell lymphoma, nasal type (ENKTL) cell proliferation and tumor growth. As SIRT5 serves as a tumor suppressor in ENKTL, it may be a promising molecular target in therapy strategy Homo sapiens
physiological function SIRT5 inhibits glycolysis via catalyzing the desuccinylation of glycolytic enzyme glucose-6-phosphate isomerase, thereby repressing extranodal natural killer/T-cell lymphoma, nasal type (ENKTL) cell proliferation and tumor growth. As SIRT5 serves as a tumor suppressor in ENKTL, it may be a promising molecular target in therapy strategy Homo sapiens
physiological function SIRT5 inhibits glycolysis via catalyzing the desuccinylation of glycolytic enzyme glucose-6-phosphate isomerase, thereby repressing extranodal natural killer/T-cell lymphoma, nasal type (ENKTL) cell proliferation and tumor growth. As SIRT5 serves as a tumor suppressor in ENKTL, it may be a promising molecular target in therapy strategy Mus musculus