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Literature summary for 2.3.1.B43 extracted from

  • Wang, Y.; Chen, H.; Zha, X.
    Overview of SIRT5 as a potential therapeutic target Structure, function and inhibitors (2022), Eur. J. Med. Chem., 236, 114363.
    View publication on PubMed
Search for more literature for 2.3.1.B43

Application

Application Comment Organism
diagnostics SIRT5 is a promising biomarker for colorectal cancer Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NXA8
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme shows low deacetylation activity but significant desuccinylation, demalonylation and deglutarylation activities Homo sapiens ?
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-
[carbamoyl phosphate synthase 1]-N6-succinyl-L-lysine + NAD+ + H2O
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 Homo sapiens [carbamoyl phosphate synthase 1]-L-lysine + 2''-O-succinyl-ADP-D-ribose + nicotinamide
-
 ?
[GLS2]-N6-succinyl-L-lysine + NAD+ + H2O
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 Homo sapiens [GLS2]-L-lysine + 2''-O-succinyl-ADP-D-ribose + nicotinamide
-
 ?

Synonyms

Synonyms Comment Organism
SIRT5
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 Homo sapiens

General Information

General Information Comment Organism
drug target SIRT5 is a promising biomarker for colorectal cancer because of its oncogenic role and SIRT5 has potential value for selective targeted therapy of colorectal cancer. SIRT5 may contribute to the development of new strategies for the treatment of gastric cancer. SIRT5 may function as a potential marker and drug target in clinical hepatocellular carcinoma diagnosis and therapy Homo sapiens
metabolism SIRT5 is closely related to some diseases such as cancer and neurodegenerative diseases Homo sapiens
physiological function SIRT5 regulates glycolysis, the TCA cycle, and the electron transport chain. SIRT5 promotes fatty acid beta-oxidation and ketone body production Homo sapiens