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Literature summary for 2.3.1.B43 extracted from

  • Nishida, Y.; Rardin, M.J.; Carrico, C.; He, W.; Sahu, A.K.; Gut, P.; Najjar, R.; Fitch, M.; Hellerstein, M.; Gibson, B.W.; Verdin, E.
    SIRT5 regulates both cytosolic and mitochondrial protein malonylation with glycolysis as a major target (2015), Mol. Cell, 59, 321-332.
    View publication on PubMed
Search for more literature for 2.3.1.B43

Protein Variants

Protein Variants Comment Organism
H158Y catalytically inactive Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD+ + [protein]-N6-malonyl-L-lysine + H2O Mus musculus
-
 nicotinamide + [protein]-L-lysine + 2'-O-malonyl-ADP-ribose
-
 ?
NAD+ + [protein]-N6-succinyl-L-lysine + H2O Mus musculus
-
 nicotinamide + [protein]-L-lysine + 2'-O-succinyl-ADP-ribose
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q8K2C6
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
heart
-
 Mus musculus
-
hepatocyte
-
 Mus musculus
-
kidney
-
 Mus musculus
-
lung
-
 Mus musculus
-
pancreas
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + [glyceraldehyde-3-phosphate dehydrogenase]-N6-malonyl-L-lysine + H2O
-
 Mus musculus nicotinamide + [glyceraldehyde-3-phosphate dehydrogenase]-L-lysine + 2'-O-malonyl-ADP-ribose
-
 ?
NAD+ + [protein]-N6-malonyl-L-lysine + H2O
-
 Mus musculus nicotinamide + [protein]-L-lysine + 2'-O-malonyl-ADP-ribose
-
 ?
NAD+ + [protein]-N6-succinyl-L-lysine + H2O
-
 Mus musculus nicotinamide + [protein]-L-lysine + 2'-O-succinyl-ADP-ribose
-
 ?

Synonyms

Synonyms Comment Organism
NAD+-dependent protein deacetylase
-
 Mus musculus
nicotinamide adenine dinucleotide-dependent protein deacetylase
-
 Mus musculus
SIRT5
-
 Mus musculus