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Literature summary for 2.3.1.B43 extracted from

  • Ringel, A.E.; Roman, C.; Wolberger, C.
    Alternate deacylating specificities of the archaeal sirtuins Sir2Af1 and Sir2Af2 (2014), Protein Sci., 23, 1686-1697.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
vapor diffusion at 20°C, crystal structure of the enzyme bound to KGLGKGGA(N6-succinyl)KRHRKW Archaeoglobus fulgidus

Organism

Organism UniProt Comment Textmining
Archaeoglobus fulgidus O28597
-
-
Escherichia coli
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Escherichia coli
-
Archaeoglobus fulgidus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + KGLGKGGA(N6-acetyl)KRHRKW the rate of desuccinylation is 2.3fold faster than the rate of deacetylation Escherichia coli nicotinamide + KGLGKGGAKRHRKW + 2'-O-acetyl-ADP-ribose
-
?
NAD+ + KGLGKGGA(N6-acetyl)KRHRKW the rate of desuccinylation is about 5fold faster than the rate of deacetylation Archaeoglobus fulgidus nicotinamide + KGLGKGGAKRHRKW + 2'-O-acetyl-ADP-ribose
-
?
NAD+ + KGLGKGGA(N6-butyryl)KRHRKW the rate of desuccinylation is 5.8fold faster than the rate of deburyrylation Escherichia coli nicotinamide + KGLGKGGAKRHRKW + 2'-O-butyryl-ADP-ribose
-
?
NAD+ + KGLGKGGA(N6-butyryl)KRHRKW the rate of desuccinylation is about 10fold faster than the rate of debutyrylation Archaeoglobus fulgidus nicotinamide + KGLGKGGAKRHRKW + 2'-O-butyryl-ADP-ribose
-
?
NAD+ + KGLGKGGA(N6-propionyl)KRHRKW the rate of desuccinylation is 3.8fold faster than the rate of depropionylation Escherichia coli nicotinamide + KGLGKGGAKRHRKW + 2'-O-propionyl-ADP-ribose
-
?
NAD+ + KGLGKGGA(N6-propionyl)KRHRKW the rate of desuccinylation is about 5fold faster than the rate of depropionylation Archaeoglobus fulgidus nicotinamide + KGLGKGGAKRHRKW + 2'-O-propionyl-ADP-ribose
-
?
NAD+ + KGLGKGGA(N6-succinyl)KRHRKW the rate of desuccinylation is 2.3fold faster than the rate of deacetylation Escherichia coli nicotinamide + KGLGKGGAKRHRKW + 2'-O-succinyl-ADP-ribose
-
?
NAD+ + KGLGKGGA(N6-succinyl)KRHRKW the rate of desuccinylation is about 5fold faster than the rate of deacetylation Archaeoglobus fulgidus nicotinamide + KGLGKGGAKRHRKW + 2'-O-succinyl-ADP-ribose
-
?

Synonyms

Synonyms Comment Organism
CobB
-
Escherichia coli
Sir2Af1
-
Archaeoglobus fulgidus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Escherichia coli
50
-
assay at Archaeoglobus fulgidus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
assay at Escherichia coli
8
-
assay at Archaeoglobus fulgidus