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Literature summary for 2.3.1.B43 extracted from

  • AbouElfetouh, A.; Kuhn, M.L.; Hu, L.I.; Scholle, M.D.; Sorensen, D.J.; Sahu, A.K.; Becher, D.; Antelmann, H.; Mrksich, M.; Anderson, W.F.; Gibson, B.W.; Schilling, B.; Wolfe, A.J.
    The E. coli sirtuin CobB shows no preference for enzymatic and nonenzymatic lysine acetylation substrate sites (2015), Microbiologyopen, 4, 66-83.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
-
 Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD+ + [protein]-N6-acetyl-L-lysine Escherichia coli the enzyme regulates protein function in diverse and often essential cellular processes, most notably translation nicotinamide + [protein]-L-lysine + 2'-O-acetyl-ADP-ribose
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli P75960
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + [protein]-N6-acetyl-L-lysine the enzyme regulates protein function in diverse and often essential cellular processes, most notably translation Escherichia coli nicotinamide + [protein]-L-lysine + 2'-O-acetyl-ADP-ribose
-
 ?
NAD+ + [protein]-N6-acetyl-L-lysine the enzyme can deacetylate acetyllysine independently whether the acetyl donor is acetyl-Coenzyme A or acetyl phosphate. Linear sequences alone are inadequate to predict CobB substrates and that structural analyses are necessary. CobB substrate acetyllyines appear to be located near the surface of the protein on a Escherichia coli nicotinamide + [protein]-L-lysine + 2'-O-acetyl-ADP-ribose
-
 ?

Synonyms

Synonyms Comment Organism
CobB
-
 Escherichia coli

General Information

General Information Comment Organism
physiological function the enzyme regulates protein function in diverse and often essential cellular processes, most notably translation. CobB is the predominate deacetylase in Escherichia coli loop or a helix that protrudes into the solution and thus in position to be an easily accessible target Escherichia coli