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Literature summary for 2.3.1.B43 extracted from

  • Madsen, A.S.; Olsen, C.A.
    Substrates for efficient fluorometric screening employing the NAD-dependent sirtuin 5 lysine deacylase (KDAC) enzyme (2012), J. Med. Chem., 55, 5582-5590.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
suramin
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.033
-
Ac-Leu-Gly-(N6-succinyl)Lys-7-amido-4-methylcoumarin pH 8.0, 37°C Homo sapiens
0.084
-
Ac-(N6-succinyl)Lys-7-amido-4-methylcoumarin pH 8.0, 37°C Homo sapiens
0.15
-
NAD+ cosubstrate: Ac-(N6-succinyl)Lys-7-amido-4-methylcoumarin, pH 8.0, 37°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NXA8
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information no activity with Ac-Leu-Gly-(N6-acetyl)Lys-7-amido-4-methylcoumarin Homo sapiens ?
-
?
NAD+ + Ac-(N6-methylmalonyl)Lys-(7-amido-4-methylcoumarin)
-
Homo sapiens nicotinamide + Ac-Lys-7-amido-4-methylcoumarin + 2'-O-methylmalonyl-ADP-ribose
-
?
NAD+ + Ac-(N6-succinyl)Lys-7-amido-4-methylcoumarin
-
Homo sapiens nicotinamide + Ac-Lys-7-amido-4-methylcoumarin + 2'-O-succinyl-ADP-ribose
-
?
NAD+ + Ac-Leu-Gly-(N6-malonyl)Lys-7-amido-4-methylcoumarin
-
Homo sapiens nicotinamide + Ac-Leu-Gly-Lys-7-amido-4-methylcoumarin + 2'-O-malonyl-ADP-ribose
-
?
NAD+ + Ac-Leu-Gly-(N6-succinyl)Lys-7-amido-4-methylcoumarin
-
Homo sapiens nicotinamide + Ac-Leu-Gly-Lys-7-amido-4-methylcoumarin + 2'-O-succinyl-ADP-ribose
-
?

Synonyms

Synonyms Comment Organism
sirtuin 5 lysine deacylase
-
Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.009
-
Ac-(N6-succinyl)Lys-7-amido-4-methylcoumarin pH 8.0, 37°C Homo sapiens
0.03
-
Ac-Leu-Gly-(N6-succinyl)Lys-7-amido-4-methylcoumarin pH 8.0, 37°C Homo sapiens

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
0.11
-
Ac-(N6-succinyl)Lys-7-amido-4-methylcoumarin pH 8.0, 37°C Homo sapiens
0.92
-
Ac-Leu-Gly-(N6-succinyl)Lys-7-amido-4-methylcoumarin pH 8.0, 37°C Homo sapiens