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Literature summary for 2.3.1.B43 extracted from
- Thiosuccinyl peptides as Sirt5-specific inhibitors (2012), J. Am. Chem. Soc., 134, 1922-1925.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (N6-thiosuccinyl)KSTGGKA | - |
Homo sapiens |  |
| Ac-AR(N6-thiosuccinyl)KST-NH2 | - |
Homo sapiens | |
| Ac-RR(N6-thiosuccinyl)KRR-NH2 | - |
Homo sapiens | |
| AGK2 | 40% inhibition at 0.1 mM | Homo sapiens | |
| AR(N6-thiosuccinyl)KST | - |
Homo sapiens | |
| KQTAR(N6-thiosuccinyl)K | - |
Homo sapiens | |
| KQTAR(N6-thiosuccinyl)KSTGGKA | - |
Homo sapiens | |
| additional information | H3K9TAc and sirtinol show no inhibnition at 0.1 mM | Homo sapiens | |
| nicotinamide | - |
Homo sapiens | |
| suramin | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9NXA8 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| NAD+ + KQTAR(N6-succinyl)KSTGGKA + H2O | - |
Homo sapiens | nicotinamide + KQTARKSTGGKA + 2'-O-succinyl-ADP-ribose | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SIRT5 | - |
Homo sapiens |
| sirtuin 5 | - |
Homo sapiens |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.001 | - |
pH and temperature not specified in the publication | Homo sapiens | KQTAR(N6-thiosuccinyl)K | |
| 0.001 | - |
pH and temperature not specified in the publication | Homo sapiens | (N6-thiosuccinyl)KSTGGKA | |
| 0.005 | - |
pH and temperature not specified in the publication | Homo sapiens | KQTAR(N6-thiosuccinyl)KSTGGKA | |
| 0.025 | - |
pH and temperature not specified in the publication | Homo sapiens | Ac-RR(N6-thiosuccinyl)KRR-NH2 | |
| 0.025 | - |
pH and temperature not specified in the publication | Homo sapiens | suramin | |
| 0.03 | - |
pH and temperature not specified in the publication | Homo sapiens | AR(N6-thiosuccinyl)KST | |
| 0.04 | - |
pH and temperature not specified in the publication | Homo sapiens | Ac-AR(N6-thiosuccinyl)KST-NH2 | |
| 0.15 | - |
pH and temperature not specified in the publication | Homo sapiens | nicotinamide | |
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