Literature summary for 2.3.1.B43 extracted from

Tan, M.; Peng, C.; Anderson, K.A.; Chhoy, P.; Xie, Z.; Dai, L.; Park, J.; Chen, Y.; Huang, H.; Zhang, Y.; Ro, J.; Wagner, G.R.; Green, M.F.; Madsen, A.S.; Schmiesing, J.; Peterson, B.S.; Xu, G.; Ilkayeva, O.R.; Muehlbauer, M.J.; Braulke, T.; M�hlhausen, C.; Backos, D.S.; Olsen, C.A.; McGuire, P.J.; Pletcher, S.D.; Lombard, D.B.; Hirschey, M.D.; Zhao, Y.
Lysine glutarylation is a protein posttranslational modification regulated by SIRT5 (2014), Cell Metab., 19, 605-617.

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
NAD+ + [carbamoyl phosphate synthetase 1]-N6-glutaryl-L-lysine + H2O	Homo sapiens	-	nicotinamide + [carbamoyl phosphate synthetase 1]-L-lysine + 2'-O-glutaryl-ADP-ribose	-	?

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9NXA8	-	-

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
NAD+ + [carbamoyl phosphate synthetase 1]-N6-glutaryl-L-lysine + H2O	-	Homo sapiens	nicotinamide + [carbamoyl phosphate synthetase 1]-L-lysine + 2'-O-glutaryl-ADP-ribose	-	?

Synonyms	Comment	Organism
SIRT5	-	Homo sapiens
sirtuin 5	-	Homo sapiens

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Release 2026.1 (March 2026)