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Literature summary for 2.3.1.B43 extracted from

  • Lin, Z.F.; Xu, H.B.; Wang, J.Y.; Lin, Q.; Ruan, Z.; Liu, F.B.; Jin, W.; Huang, H.H.; Chen, X.
    SIRT5 desuccinylates and activates SOD1 to eliminate ROS (2013), Biochem. Biophys. Res. Commun., 441, 191-195.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD+ + [Cu/Zn superoxide dismutase]-N6-succinyl-L-lysine123 + H2O Homo sapiens SIRT5 binds to, desuccinylates and activates the key antioxidant enzyme Cu/Zn superoxide dismutase (SOD1). SOD1-mediated reduction of reactive oxygen species (ROS) is increased when SIRT5 is co-expressed. Posttranslational regulation of SOD1 by means of succinylation and SIRT5-dependent desuccinylation is important for the growth of lung tumor cells nicotinamide + [Cu/Zn superoxide dismutase]-L-lysine123 + 2'-O-succinyl-ADP-ribose
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Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NXA8
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + [Cu/Zn superoxide dismutase]-N6-succinyl-L-lysine123 + H2O SIRT5 binds to, desuccinylates and activates the key antioxidant enzyme Cu/Zn superoxide dismutase (SOD1). SOD1-mediated reduction of reactive oxygen species (ROS) is increased when SIRT5 is co-expressed. Posttranslational regulation of SOD1 by means of succinylation and SIRT5-dependent desuccinylation is important for the growth of lung tumor cells Homo sapiens nicotinamide + [Cu/Zn superoxide dismutase]-L-lysine123 + 2'-O-succinyl-ADP-ribose
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 ?
NAD+ + [Cu/Zn superoxide dismutase]-N6-succinyl-L-lysine123 + H2O
-
 Homo sapiens nicotinamide + [Cu/Zn superoxide dismutase]-L-lysine123 + 2'-O-succinyl-ADP-ribose
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 ?

Synonyms

Synonyms Comment Organism
SIRT5
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 Homo sapiens