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Literature summary for 2.3.1.B43 extracted from

  • Roessler, C.; Nowak, T.; Pannek, M.; Gertz, M.; Nguyen, G.T.; Scharfe, M.; Born, I.; Sippl, W.; Steegborn, C.; Schutkowski, M.
    Chemical probing of the human sirtuin 5 active site reveals its substrate acyl specificity and peptide-based inhibitors (2014), Angew. Chem. Int. Ed. Engl., 53, 10728-10732.
    View publication on PubMed
Search for more literature for 2.3.1.B43

Inhibitors

Inhibitors Comment Organism Structure
benzoyl-GVL(N6-(3-acetylthiosuccinyl))KEYGV-amide
-
 Homo sapiens
benzoyl-GVL(N6-(3-butylsuccinyl))KEYGV-amide
-
 Homo sapiens
benzoyl-GVL(N6-(3-methyl-3-phenyl)succinyl)KEYGV-amide
-
 Homo sapiens
benzoyl-GVL(N6-(3-phenyl)succinyl)KEYGV-amide
-
 Homo sapiens
benzoyl-GVL(N6-(N-benzyloxycarbonyl-L-aspartyl))KEYGV-amide
-
 Homo sapiens
benzoyl-GVL(N6-(N-phthaloyl-DL-gamma-glutamyl))KEYGV-amide
-
 Homo sapiens
benzoyl-GVL(N6-(N2-Fmoc-beta-L-aspartyl))KEYGV-amide
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0038
-
 benzoyl-GVL(N6-succinyl)KEYGV-amide pH 7.8, 37°C Homo sapiens
0.0041
-
 benzoyl-GVL(N6-glutaryl)KEYGV-amide pH 7.8, 37°C Homo sapiens
0.0051
-
 benzoyl-GVL(N6-malonyl)KEYGV-amide pH 7.8, 37°C Homo sapiens
0.0065
-
 benzoyl-GVL(N6-adipoyl)KEYGV-amide pH 7.8, 37°C Homo sapiens
0.0243
-
 benzoyl-GVL(N6-acetyl)KEYGV-amide pH 7.8, 37°C Homo sapiens
0.0805
-
 benzoyl-GVL(N6-pimeloyl)KEYGV-amide pH 7.8, 37°C Homo sapiens
0.409
-
 benzoyl-GVL(N6-suberoyl)KEYGV-amide pH 7.8, 37°C Homo sapiens
0.416
-
 benzoyl-GVL(N6-oxalyl)KEYGV-amide pH 7.8, 37°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NXA8
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + benzoyl-GVL(N6-acetyl)KEYGV-amide + H2O
-
 Homo sapiens nicotinamide + benzoyl-GVLKEYGV-amide + 2'-O-acetyl-ADP-ribose
-
 ?
NAD+ + benzoyl-GVL(N6-adipoyl)KEYGV-amide + H2O
-
 Homo sapiens nicotinamide + benzoyl-GVLKEYGV-amide + 2'-O-adipoyl-ADP-ribose
-
 ?
NAD+ + benzoyl-GVL(N6-glutaryl)KEYGV-amide + H2O
-
 Homo sapiens nicotinamide + benzoyl-GVLKEYGV-amide + 2'-O-glutaryl-ADP-ribose
-
 ?
NAD+ + benzoyl-GVL(N6-malonyl)KEYGV-amide + H2O
-
 Homo sapiens nicotinamide + benzoyl-GVLKEYGV-amide + 2'-O-malonyl-ADP-ribose
-
 ?
NAD+ + benzoyl-GVL(N6-oxalyl)KEYGV-amide + H2O
-
 Homo sapiens nicotinamide + benzoyl-GVLKEYGV-amide + 2'-O-oxalyl-ADP-ribose
-
 ?
NAD+ + benzoyl-GVL(N6-pimeloyl)KEYGV-amide + H2O
-
 Homo sapiens nicotinamide + benzoyl-GVLKEYGV-amide + 2'-O-pimeloyl-ADP-ribose
-
 ?
NAD+ + benzoyl-GVL(N6-suberoyl)KEYGV-amide + H2O
-
 Homo sapiens nicotinamide + benzoyl-GVLKEYGV-amide + 2'-O-suberoyl-ADP-ribose
-
 ?
NAD+ + benzoyl-GVL(N6-succinyl)KEYGV-amide + H2O
-
 Homo sapiens nicotinamide + benzoyl-GVLKEYGV-amide + 2'-O-succinyl-ADP-ribose
-
 ?

Synonyms

Synonyms Comment Organism
sirtuin 5
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.00028
-
 benzoyl-GVL(N6-pimeloyl)KEYGV-amide pH 7.8, 37°C Homo sapiens
0.00039
-
 benzoyl-GVL(N6-acetyl)KEYGV-amide pH 7.8, 37°C Homo sapiens
0.00053
-
 benzoyl-GVL(N6-suberoyl)KEYGV-amide pH 7.8, 37°C Homo sapiens
0.0016
-
 benzoyl-GVL(N6-oxalyl)KEYGV-amide pH 7.8, 37°C Homo sapiens
0.01
-
 benzoyl-GVL(N6-adipoyl)KEYGV-amide pH 7.8, 37°C Homo sapiens
0.019
-
 benzoyl-GVL(N6-malonyl)KEYGV-amide pH 7.8, 37°C Homo sapiens
0.053
-
 benzoyl-GVL(N6-succinyl)KEYGV-amide pH 7.8, 37°C Homo sapiens
0.077
-
 benzoyl-GVL(N6-glutaryl)KEYGV-amide pH 7.8, 37°C Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.8
-
 assay at Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0043
-
 benzoyl-GVL(N6-(3-methyl-3-phenyl)succinyl)KEYGV-amide pH 7.8, 37°C Homo sapiens
0.0106
-
 benzoyl-GVL(N6-(3-acetylthiosuccinyl))KEYGV-amide pH 7.8, 37°C Homo sapiens
0.0172
-
 benzoyl-GVL(N6-(3-butylsuccinyl))KEYGV-amide pH 7.8, 37°C Homo sapiens
0.0249
-
 benzoyl-GVL(N6-(N-phthaloyl-DL-gamma-glutamyl))KEYGV-amide pH 7.8, 37°C Homo sapiens
0.0381
-
 benzoyl-GVL(N6-(N-benzyloxycarbonyl-L-aspartyl))KEYGV-amide pH 7.8, 37°C Homo sapiens
0.046
-
 benzoyl-GVL(N6-(N2-Fmoc-beta-L-aspartyl))KEYGV-amide pH 7.8, 37°C Homo sapiens
0.1
-
 benzoyl-GVL(N6-(3-phenyl)succinyl)KEYGV-amide pH 7.8, 37°C Homo sapiens

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
0.001
-
 benzoyl-GVL(N6-suberoyl)KEYGV-amide pH 7.8, 37°C Homo sapiens
0.004
-
 benzoyl-GVL(N6-oxalyl)KEYGV-amide pH 7.8, 37°C Homo sapiens
0.004
-
 benzoyl-GVL(N6-pimeloyl)KEYGV-amide pH 7.8, 37°C Homo sapiens
0.016
-
 benzoyl-GVL(N6-acetyl)KEYGV-amide pH 7.8, 37°C Homo sapiens
1.54
-
 benzoyl-GVL(N6-adipoyl)KEYGV-amide pH 7.8, 37°C Homo sapiens
3.76
-
 benzoyl-GVL(N6-malonyl)KEYGV-amide pH 7.8, 37°C Homo sapiens
13.9
-
 benzoyl-GVL(N6-succinyl)KEYGV-amide pH 7.8, 37°C Homo sapiens
18.7
-
 benzoyl-GVL(N6-glutaryl)KEYGV-amide pH 7.8, 37°C Homo sapiens