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Literature summary for 2.3.1.B43 extracted from

  • Nakagawa, T.; Guarente, L.
    Urea cycle regulation by mitochondrial sirtuin, SIRT5 (2009), Aging, 1, 578-581.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.B43

Application

Application Comment Organism
medicine SIRT5 may have therapeutic value to treat hyperammonemia Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial matrix
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 Mus musculus 5759
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD+ + [carbamoyl phosphate synthase 1]-N6-acetyl-L-lysine Mus musculus SIRT5 deacetylates carbamoyl phosphate synthetase 1 (CPS1), an enzyme which is the first and rate-limiting step of urea cycle. Deacetylation of CPS1 by SIRT5 results in activation of CPS1 enzymatic activity nicotinamide + [carbamoyl phosphate synthase 1]-L-lysine + 2'-O-acetyl-ADP ribose
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q8K2C6
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-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + [carbamoyl phosphate synthase 1]-N6-acetyl-L-lysine
-
 Mus musculus nicotinamide + [carbamoyl phosphate synthase 1]-L-lysine + 2'-O-acetyl-ADP ribose
-
 ?
NAD+ + [carbamoyl phosphate synthase 1]-N6-acetyl-L-lysine SIRT5 deacetylates carbamoyl phosphate synthetase 1 (CPS1), an enzyme which is the first and rate-limiting step of urea cycle. Deacetylation of CPS1 by SIRT5 results in activation of CPS1 enzymatic activity Mus musculus nicotinamide + [carbamoyl phosphate synthase 1]-L-lysine + 2'-O-acetyl-ADP ribose
-
 ?

Synonyms

Synonyms Comment Organism
SIRT5
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 Mus musculus

General Information

General Information Comment Organism
metabolism SIRT5 deacetylates carbamoyl phosphate synthetase 1 (CPS1), an enzyme which is the first and rate-limiting step of urea cycle. Deacetylation of CPS1 by SIRT5 results in activation of CPS1 enzymatic activity Mus musculus
metabolism SIRT5 has an emerging role in the metabolic adaptation to fasting, high protein diet and calorie restriction Mus musculus