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Literature summary for 2.3.1.B43 extracted from

  • Nakagawa, T.; Lomb, D.J.; Haigis, M.C.; Guarente, L.
    SIRT5 deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle (2009), Cell, 137, 560-570.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.B43

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial matrix
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 Mus musculus 5759
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD+ + [carbamoyl phosphate synthetase 1]-N6-acetyl-L-lysine Mus musculus SIRT5 plays a pivotal role in ammonia detoxification and disposal by activating carbamoyl phosphate synthetase 1 (CPS1) an enzyme, catalyzing the initial step of the urea cycle for ammonia detoxification and disposal. SIRT5 deacetylates CPS1 and up-regulates its activity. During fasting, NAD+ in liver mitochondria increases, thereby triggering SIRT5 deacetylation of CPS1 and adaptation to the increase in amino acid catabolism. Indeed, SIRT5 KO mice fail to up-regulate CPS1 activity and show elevated blood ammonia during fasting nicotinamide + [carbamoyl phosphate synthetase 1]-L-lysine + 2'-O-acetyl-ADP ribose
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q8K2C6
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + [carbamoyl phosphate synthetase 1]-N6-acetyl-L-lysine
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 Mus musculus nicotinamide + [carbamoyl phosphate synthetase 1]-L-lysine + 2'-O-acetyl-ADP ribose
-
 ?
NAD+ + [carbamoyl phosphate synthetase 1]-N6-acetyl-L-lysine SIRT5 plays a pivotal role in ammonia detoxification and disposal by activating carbamoyl phosphate synthetase 1 (CPS1) an enzyme, catalyzing the initial step of the urea cycle for ammonia detoxification and disposal. SIRT5 deacetylates CPS1 and up-regulates its activity. During fasting, NAD+ in liver mitochondria increases, thereby triggering SIRT5 deacetylation of CPS1 and adaptation to the increase in amino acid catabolism. Indeed, SIRT5 KO mice fail to up-regulate CPS1 activity and show elevated blood ammonia during fasting Mus musculus nicotinamide + [carbamoyl phosphate synthetase 1]-L-lysine + 2'-O-acetyl-ADP ribose
-
 ?

Synonyms

Synonyms Comment Organism
SIRT5
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 Mus musculus

General Information

General Information Comment Organism
metabolism SIRT5 plays a pivotal role in ammonia detoxification and disposal by activating carbamoyl phosphate synthetase 1 an enzyme, catalyzing the initial step of the urea cycle for ammonia detoxification and disposal Mus musculus