Literature summary for 2.3.1.B43 extracted from

Starai, V.J.; Celic, I.; Cole, R.N.; Boeke, J.D.; Escalante-Semerena, J.C.
Sir2-dependent activation of acetyl-CoA synthetase by deacetylation of active lysine (2002), Science, 298, 2390-2392.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
NAD+ + [acetyl-coenzyme A synthetase]-N6-acetyl-L-lysine609	Salmonella enterica	deacetylation by CobB activates the acetyl-coenzyme A synthetase	nicotinamide + [acetyl-coenzyme A synthetase]-L-lysine609 + 2'-O-acetyl-ADP-ribose	-	?

Organism

Organism	UniProt	Comment	Textmining
Salmonella enterica	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
NAD+ + [acetyl-coenzyme A synthetase]-N6-acetyl-L-lysine609	-	Salmonella enterica	nicotinamide + [acetyl-coenzyme A synthetase]-L-lysine609 + 2'-O-acetyl-ADP-ribose	-	?
NAD+ + [acetyl-coenzyme A synthetase]-N6-acetyl-L-lysine609	deacetylation by CobB activates the acetyl-coenzyme A synthetase	Salmonella enterica	nicotinamide + [acetyl-coenzyme A synthetase]-L-lysine609 + 2'-O-acetyl-ADP-ribose	-	?

Synonyms

Synonyms	Comment	Organism
CobB Sir2 protein	-	Salmonella enterica

General Information

General Information	Comment	Organism
malfunction	acetyl-coenzyme A synthetase overproduced by the cobB deletion mutant strain contains acetyllysine at residue Lys609	Salmonella enterica
physiological function	deacetylation by CobB activates the acetyl-coenzyme A synthetase	Salmonella enterica

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Release 2023.1 (January 2023)