Literature summary for 2.3.1.B41 extracted from

Sociali, G.; Liessi, N.; Grozio, A.; Caffa, I.; Parenti, M.; Ravera, S.; Tasso, B.; Benzi, A.; Nencioni, A.; Del Rio, A.; Robina, I.; Millo, E.; Bruzzone, S.
Differential modulation of SIRT6 deacetylase and deacylase activities by lysine-based small molecules (2019), Mol. Divers., 24, 655-671 .

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Protein Variants

Protein Variants	Comment	Organism
G60A	the SIRT6 G60A mutant retains an efficient defatty-acylase activity, but has significantly decreased deacetylase activity	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
(9H-fluoren-9-yl)methyl(6-acetamido-1-(dodecylamino)-1-oxohexan-2-yl)carbamate	-	Homo sapiens
(9H-fluoren-9-yl)methyl(6-acetamido-1-(dodecylamino)-1-oxohexanyl) carbamate	-	Homo sapiens
2,4-dioxo-N-(4-(pyridin-3-yloxy)phenyl)-1,2,3,4-tetrahydroquinazoline-6-sulfonamide	i.e. compound Q, a SIRT6 inhibitor with quinazolinedione-like structure, which reduces both SIRT6 deacetylase and deacylase activities	Homo sapiens
2,6-diamino-N-dodecylhexanamide	-	Homo sapiens
2,6-diamino-N-octadecylhexanamide	-	Homo sapiens
2-acetamido-6-amino-N-octadecylhexanamide	-	Homo sapiens
2-acetamido-6-amino-N-tetradecylhexanamide	-	Homo sapiens
additional information	identification of SIRT6 inhibitors that decrease SIRT6 deacetylase activity and evoke coherent biological effects in cells. These inhibitors include a family of compounds with a quinazolinedione-based structure and a family of compounds with salicylate-based structure, with an IC50 for the SIRT6-catalyzed deacetylase activity in the low micromolar range. Relative enzyme activity in presencee of inhibitors compared to control, overview. No inhibition by (9H-fluoren-9-yl)methyl [(2S)-6-[(tert-butoxycarbonyl)amino]-1-(dodecylamino)-1-oxohexan-2-yl]carbamate and tert-butyl [(5S)-5-acetamido-6-(dodecylamino)-6-oxohexyl]carbamate	Homo sapiens
N,N'-(6-(octadecylamino)-6-oxohexane-1,5-diyl)diacetamide	-	Homo sapiens
N-[(5S)-5-acetamido-6-(dodecylamino)-6-oxohexyl]-N,N-dimethylmethanaminium	-	Homo sapiens
N2-acetyl-N-dodecyl-L-lysinamide	-	Homo sapiens
tert-butyl (5-acetamido-6-(octadecylamino)-6-oxohexyl)carbamate	-	Homo sapiens
tert-butyl (5-amino-6-(dodecylamino)-6-oxohexyl)carbamate	-	Homo sapiens
tert-butyl (5-amino-6-(octadecylamino)-6-oxohexyl)carbamate	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	sirtuin6 performs H3K9 acetylation on histone H3, cf. EC 2.3.1.286	?	-	-
NAD+ + [protein]-N6-palmitoyl-L-lysine	Homo sapiens	-	nicotinamide + [protein]-L-lysine + 2'-O-palmitoyl-ADP ribose	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q8N6T7	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
MCF-7 cell	-	Homo sapiens	-
THP-1 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	sirtuin6 performs H3K9 acetylation on histone H3, cf. EC 2.3.1.286	Homo sapiens	?	-	-
additional information	a myristoyl peptide and a palmitoyl peptide are incubated with sirtuin6. Sirtuin6 exhibits both SIRT6 deacetylase and deacylase activities, cf. EC 2.3.1.286	Homo sapiens	?	-	-
NAD+ + [protein]-N6-palmitoyl-L-lysine	-	Homo sapiens	nicotinamide + [protein]-L-lysine + 2'-O-palmitoyl-ADP ribose	-	?

Synonyms

Synonyms	Comment	Organism
SIRT6	-	Homo sapiens
SIRT6 deacylase	-	Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.4	-	assay at	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	SIRT6 seems to act as an oncogene, by virtue of its ability to promote DNA repair, cancer cell invasiveness and inflammation	Homo sapiens

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Release 2023.1 (January 2023)