Literature summary for 2.3.1.B41 extracted from

Tian, K.; Liu, Z.; Wang, J.; Xu, S.; You, T.; Liu, P.
Sirtuin-6 inhibits cardiac fibroblasts differentiation into myofibroblasts via inactivation of nuclear factor kappaB signaling (2015), Transl. Res., 165, 374-386.

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Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	Q4FZY2	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
cardiac fibroblast	-	Rattus norvegicus	-

Synonyms

Synonyms	Comment	Organism
SIRT6	-	Rattus norvegicus
sirtuin-6	-	Rattus norvegicus

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	dependent on	Rattus norvegicus

Expression

Organism	Comment	Expression
Rattus norvegicus	SIRT6 expression is upregulated under pathologic conditions in angiotensin II-stimulated cardiac fibroblasts and in myocardium of rat subjected to abdominal aortic constriction surgery	up

General Information

General Information	Comment	Organism
malfunction	SIRT6 depletion in cardiac fibroblasts results in increased cell proliferation and extracellular matrix deposition as well as significantly higher expression of alpha-smooth muscle actin, the classical marker of myofibroblast differentiation, and increased formation of focal adhesions. Notably, SIRT6 depletion further exacerbates angiotensin IIinduced myofibroblast differentiation	Rattus norvegicus
physiological function	the enzyme is a key modulator in the phenotypic conversion of cardiac fibroblasts to myofibroblasts	Rattus norvegicus

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Release 2023.1 (January 2023)