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Literature summary for 2.3.1.B41 extracted from
- Cyclic peptide-based potent human SIRT6 inhibitors (2016), Org. Biomol. Chem., 14, 5928-5935.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| H2N-AK-(N(epsilon)-thioacetyl-)lysine-LM-COOH | moderate potent inhibitor | Homo sapiens |  |
| H2N-HK-(N(epsilon)-thioacetyl-)lysine-LM-COOH | moderate potent inhibitor | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| NAD+ + [histone H3]-N6-acetyl-L-lysine9 | Homo sapiens | - |
nicotinamide + [histone H3]-L-lysine + 2'-O-acetyl-ADP ribose | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q8N6T7 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| NAD+ + [histone H3]-N6-acetyl-L-lysine9 | - |
Homo sapiens | nicotinamide + [histone H3]-L-lysine + 2'-O-acetyl-ADP ribose | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SIRT6 | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | dependent on | Homo sapiens | |
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Release 2023.1 (January 2023)
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