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Literature summary for 2.3.1.B41 extracted from

  • Zhang, X.; Khan, S.; Jiang, H.; Antonyak, M.A.; Chen, X.; Spiegelman, N.A.; Shrimp, J.H.; Cerione, R.A.; Lin, H.
    Identifying the functional contribution of the defatty-acylase activity of SIRT6 (2016), Nat. Chem. Biol., 12, 614-620.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.B41

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) and NIH-3T3 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
G60A the mutant is a lysine defatty acylase in vitro with substantially decreased deacetylase activity in vitro and no detectable deacetylase activity in cells Homo sapiens
H133Y inactive Homo sapiens
R65A the mutant shows only ADP-ribosyltransferase activity but no deacetylase activity Homo sapiens
S56Y inactive Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8N6T7
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + [histone H3]-N6-acetyl-L-lysine9
-
 Homo sapiens nicotinamide + [histone H3]-L-lysine + 2'-O-acetyl-ADP ribose
-
 ?
NAD+ + [histone H3]-N6-myristoyl-L-lysine
-
 Homo sapiens nicotinamide + [histone H3]-L-lysine + 2'-O-myristoyl-ADP ribose
-
 ?
NAD+ + [histone H3]-N6-palmitoyl-L-lysine
-
 Homo sapiens nicotinamide + [histone H3]-L-lysine + 2'-O-palmitoyl-ADP ribose
-
 ?
NAD+ + [tumor necrosis factor-alpha]-N6-acetyl-L-lysine9
-
 Homo sapiens nicotinamide + [tumor necrosis factor-alpha]-L-lysine + 2'-O-acetyl-ADP ribose
-
 ?

Synonyms

Synonyms Comment Organism
SIRT6
-
 Homo sapiens
sirtuin 6
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+ dependent on Homo sapiens

General Information

General Information Comment Organism
metabolism the enzyme promotes TNF-alpha secretion by defatty acylation Homo sapiens