Literature summary for 2.3.1.B41 extracted from

Zhang, J.; Yin, X.J.; Xu, C.J.; Ning, Y.X.; Chen, M.; Zhang, H.; Chen, S.F.; Yao, L.Q.
The histone deacetylase SIRT6 inhibits ovarian cancer cell proliferation via down-regulation of Notch 3 expression (2015), Eur. Rev. Med. Pharmacol. Sci., 19, 818-824.

Search for more literature for 2.3.1.B41

Application

Application	Comment	Organism
medicine	the enzyme is a therapeutic target for ovarian cancer therapy	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q8N6T7	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
ovarian cancer cell	-	Homo sapiens	-
OVCAR-3 cell	-	Homo sapiens	-
SKOV-3 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
SIRT6	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	dependent on	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	enzyme expression is significantly reduced in human ovarian cancer tissues compared to the normal tissues	down

General Information

General Information	Comment	Organism
physiological function	enzyme overexpression inhibits the proliferation of ovarian cancer cells SKOV-3 and OVCAR-3. The enzyme suppresses the expression of Notch 3 both at the mRNA and protein levels in ovarian cancer cells	Homo sapiens

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Release 2023.1 (January 2023)