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Literature summary for 2.3.1.B41 extracted from

  • Rahnasto-Rilla, M.; Kokkola, T.; Jarho, E.; Lahtela-Kakkonen, M.; Moaddel, R.
    N-acylethanolamines bind to SIRT6 (2016), ChemBioChem, 17, 77-81.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.B41

Activating Compound

Activating Compound Comment Organism Structure
linoleic acid EC50 value of 0.089 mM Homo sapiens
luteolin EC50 value of 0.27 mM Homo sapiens
additional information the enzyme activity is not stimulated by N-stearoylethanolamine and N-arachidonoylethanolamine Homo sapiens
N-(alpha-linolenoyl)ethanolamine
-
 Homo sapiens
N-(gama-linolenoyl)ethanolamine
-
 Homo sapiens
N-linoleoylethanolamine
-
 Homo sapiens
N-myristoylethanolamine
-
 Homo sapiens
N-myristoylethanolamine EC50 value of 0.0075 mM Homo sapiens
N-oleoylethanolamine strongest activator with EC50 value of 0.0031 mM Homo sapiens
N-palmitoleoylethanolamine
-
 Homo sapiens
N-palmitoylethanolamine
-
 Homo sapiens
oleic acid EC50 value of 0.23 mM Homo sapiens
quercetin EC50 value of 0.99 mM Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
luteolin 30% inhibition at 0.1 mM Homo sapiens
additional information not inhibited by linoleic acid, oleic acid, oleoylethanolamide, and myristoylethanolamide Homo sapiens
quercetin 38% inhibition at 0.1 mM Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.232
-
 [histone 3]-N6-acetyl-L-lysine9 at pH 8.0 and 37°C Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme preferentially hydrolyzes long-chain fatty acyl groups over acetyl groups in vitro ?
-
 ?
NAD+ + [histone 3]-N6-palmitoyl-L-lysine Homo sapiens
-
 nicotinamide + [histone 3]-L-lysine + 2'-O-palmitoyl-ADP ribose
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8N6T7
-
-

Purification (Commentary)

Purification (Comment) Organism
glutathione agarose column chromatography Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme preferentially hydrolyzes long-chain fatty acyl groups over acetyl groups in vitro Homo sapiens ?
-
 ?
NAD+ + [histone 3]-N6-acetyl-L-lysine9
-
 Homo sapiens nicotinamide + [histone 3]-L-lysine + 2'-O-acetyl-ADP ribose
-
 ?
NAD+ + [histone 3]-N6-palmitoyl-L-lysine
-
 Homo sapiens nicotinamide + [histone 3]-L-lysine + 2'-O-palmitoyl-ADP ribose
-
 ?

Synonyms

Synonyms Comment Organism
SIRT6
-
 Homo sapiens
sirtuin 6
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+ dependent on Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0041
-
 at pH 8.0 and 37°C Homo sapiens luteolin
0.024
-
 at pH 8.0 and 37°C Homo sapiens quercetin