Literature summary for 2.3.1.B41 extracted from

Feng, X.X.; Luo, J.; Liu, M.; Yan, W.; Zhou, Z.Z.; Xia, Y.J.; Tu, W.; Li, P.Y.; Feng, Z.H.; Tian, D.A.
Sirtuin 6 promotes transforming growth factor-beta1/H2O2/HOCl-mediated enhancement of hepatocellular carcinoma cell tumorigenicity by suppressing cellular senescence (2015), Cancer Sci., 106, 559-566.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
NAD+ + [protein]-N6-palmitoyl-L-lysine	Homo sapiens	-	nicotinamide + [protein]-L-lysine + 2'-O-palmitoyl-ADP ribose	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q8N6T7	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Hep-G2 cell	-	Homo sapiens	-
hepatocellular carcinoma cell	-	Homo sapiens	-
Huh-7 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
NAD+ + [protein]-N6-palmitoyl-L-lysine	-	Homo sapiens	nicotinamide + [protein]-L-lysine + 2'-O-palmitoyl-ADP ribose	-	?

Synonyms

Synonyms	Comment	Organism
SIRT6	-	Homo sapiens
sirtuin 6	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	dependent on	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	enzyme expression in HCC cells is upregulated by transforming growth factor-beta1, H2O2, and HOCl	up

General Information

General Information	Comment	Organism
physiological function	the upregulation of SIRT6 expression is required for transforming growth factor-beta1 and H2O2 /HOCl reactive oxygen species to promote the tumorigenicity of hepatocellular carcinoma cells. The enzyme contributes to inhibitory effect of ERK pathway on cellular senescence	Homo sapiens

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Release 2023.1 (January 2023)