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Literature summary for 2.3.1.97 extracted from
- Discovery of Plasmodium vivax N-myristoyltransferase inhibitors: screening, synthesis, and structural characterization of their binding mode (2012), J. Med. Chem., 55, 3578-3582.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1-[(diethylamino)methyl]naphthalen-2-ol | - |
Plasmodium vivax |  |
| 2-[(4-methoxybenzyl)amino]-5,5-dimethyl-4,7-dihydro-5H-thieno[2,3-c]pyran-3-carbonitrile | - |
Plasmodium vivax | |
| 3-butyl-4-(but-3-yn-1-ylsulfanyl)-6-methoxy-2-methylquinoline | - |
Plasmodium vivax | |
| 3-butyl-6-methoxy-2-methyl-4-[(2-phenylethyl)sulfanyl]quinoline | - |
Plasmodium vivax | |
| 3-[(2-bromo-3-butyl-6-methoxyquinolin-4-yl)sulfanyl]propanenitrile | - |
Plasmodium vivax | |
| 3-[(3-butyl-6-methoxy-2-methylquinolin-4-yl)sulfanyl]propan-1-ol | - |
Plasmodium vivax | |
| 3-[(3-butyl-6-methoxy-2-methylquinolin-4-yl)sulfanyl]propanenitrile | - |
Plasmodium vivax | |
| 3-[(3-butyl-6-methoxyquinolin-4-yl)sulfanyl]propanenitrile | - |
Plasmodium vivax | |
| 3-[(3-ethyl-6-methoxy-2-methylquinolin-4-yl)sulfanyl]propanenitrile | - |
Plasmodium vivax | |
| 3-[(6-methoxy-2-methylquinolin-4-yl)sulfanyl]propanenitrile | - |
Plasmodium vivax | |
| 4-[(3-butyl-6-methoxy-2-methylquinolin-4-yl)sulfanyl]butanenitrile | - |
Plasmodium vivax | |
| 6-ethyl-3-(trifluoromethyl)-2,3-dihydro-1,4-benzoxathiine 4,4-dioxide | - |
Plasmodium vivax | |
| ethyl 4-(but-3-yn-1-ylsulfanyl)-6-(1-hydroxyethyl)quinoline-3-carboxylate | - |
Plasmodium vivax | |
| ethyl 4-(but-3-yn-1-ylsulfanyl)-6-chloroquinoline-3-carboxylate | - |
Plasmodium vivax | |
| ethyl 4-(but-3-yn-1-ylsulfanyl)-6-fluoroquinoline-3-carboxylate | - |
Plasmodium vivax | |
| ethyl 4-(but-3-yn-1-ylsulfanyl)-6-methylquinoline-3-carboxylate | - |
Plasmodium vivax | |
| ethyl 4-[(2-cyanoethyl)amino]quinoline-3-carboxylate | - |
Plasmodium vivax | |
| ethyl 4-[(2-cyanoethyl)sulfanyl]-2-ethylquinoline-3-carboxylate | - |
Plasmodium vivax | |
| ethyl 4-[(2-cyanoethyl)sulfanyl]-2-methylquinoline-3-carboxylate | - |
Plasmodium vivax | |
| ethyl 4-[(2-cyanoethyl)sulfanyl]-2-propylquinoline-3-carboxylate | - |
Plasmodium vivax | |
| ethyl 4-[(2-cyanoethyl)sulfanyl]-6-methoxyquinoline-3-carboxylate | - |
Plasmodium vivax | |
| ethyl 4-[(2-cyanoethyl)sulfanyl]quinoline-3-carboxylate | - |
Plasmodium vivax | |
| ethyl 6-acetyl-4-(but-3-yn-1-ylsulfanyl)quinoline-3-carboxylate | - |
Plasmodium vivax | |
| additional information | NMT inhibitors: screening, synthesis, and structural characterization of their binding mode, overview | Plasmodium vivax | |
| [(3-butyl-6-methoxy-2-methylquinolin-4-yl)sulfanyl]acetonitrile | - |
Plasmodium vivax | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00571 | - |
peptide pp60src(2-16) | pH and temperature not specified in the publication | Plasmodium vivax |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Plasmodium vivax | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| myristoyl-CoA + peptide pp60src(2-16) | sequence GSNKSKPKDASQRRR-NH2 | Plasmodium vivax | CoA + N-myristoyl-peptideHs pp60src(2-16) | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| N-myristoyltransferase | - |
Plasmodium vivax |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00246 | - |
3-[(3-butyl-6-methoxyquinolin-4-yl)sulfanyl]propanenitrile | pH and temperature not specified in the publication | Plasmodium vivax | |
| 0.0029 | - |
3-[(3-butyl-6-methoxy-2-methylquinolin-4-yl)sulfanyl]propanenitrile | pH and temperature not specified in the publication | Plasmodium vivax | |
| 0.00323 | - |
3-[(3-ethyl-6-methoxy-2-methylquinolin-4-yl)sulfanyl]propanenitrile | pH and temperature not specified in the publication | Plasmodium vivax | |
| 0.00697 | - |
ethyl 4-(but-3-yn-1-ylsulfanyl)-6-methylquinoline-3-carboxylate | pH and temperature not specified in the publication | Plasmodium vivax | |
| 0.00777 | - |
ethyl 4-(but-3-yn-1-ylsulfanyl)-6-fluoroquinoline-3-carboxylate | pH and temperature not specified in the publication | Plasmodium vivax | |
| 0.0109 | - |
ethyl 4-(but-3-yn-1-ylsulfanyl)-6-chloroquinoline-3-carboxylate | pH and temperature not specified in the publication | Plasmodium vivax | |
| 0.0114 | - |
6-ethyl-3-(trifluoromethyl)-2,3-dihydro-1,4-benzoxathiine 4,4-dioxide | pH and temperature not specified in the publication | Plasmodium vivax | |
| 0.0116 | - |
3-butyl-4-(but-3-yn-1-ylsulfanyl)-6-methoxy-2-methylquinoline | pH and temperature not specified in the publication | Plasmodium vivax | |
| 0.0174 | - |
3-[(3-butyl-6-methoxy-2-methylquinolin-4-yl)sulfanyl]propan-1-ol | pH and temperature not specified in the publication | Plasmodium vivax | |
| 0.0216 | - |
3-[(2-bromo-3-butyl-6-methoxyquinolin-4-yl)sulfanyl]propanenitrile | pH and temperature not specified in the publication | Plasmodium vivax | |
| 0.02437 | - |
ethyl 4-[(2-cyanoethyl)sulfanyl]-2-methylquinoline-3-carboxylate | above, pH and temperature not specified in the publication | Plasmodium vivax | |
| 0.02442 | - |
ethyl 4-[(2-cyanoethyl)sulfanyl]quinoline-3-carboxylate | pH and temperature not specified in the publication | Plasmodium vivax | |
| 0.0263 | - |
1-[(diethylamino)methyl]naphthalen-2-ol | pH and temperature not specified in the publication | Plasmodium vivax | |
| 0.0264 | - |
2-[(4-methoxybenzyl)amino]-5,5-dimethyl-4,7-dihydro-5H-thieno[2,3-c]pyran-3-carbonitrile | pH and temperature not specified in the publication | Plasmodium vivax | |
| 0.0352 | - |
4-[(3-butyl-6-methoxy-2-methylquinolin-4-yl)sulfanyl]butanenitrile | pH and temperature not specified in the publication | Plasmodium vivax | |
| 0.0424 | - |
ethyl 4-[(2-cyanoethyl)sulfanyl]-6-methoxyquinoline-3-carboxylate | pH and temperature not specified in the publication | Plasmodium vivax | |
| 0.0606 | - |
ethyl 4-[(2-cyanoethyl)sulfanyl]-2-ethylquinoline-3-carboxylate | pH and temperature not specified in the publication | Plasmodium vivax | |
| 0.1 | - |
3-[(6-methoxy-2-methylquinolin-4-yl)sulfanyl]propanenitrile | above, pH and temperature not specified in the publication | Plasmodium vivax | |
| 0.1 | - |
ethyl 4-[(2-cyanoethyl)sulfanyl]-2-propylquinoline-3-carboxylate | above, pH and temperature not specified in the publication | Plasmodium vivax | |
| 0.1 | - |
[(3-butyl-6-methoxy-2-methylquinolin-4-yl)sulfanyl]acetonitrile | above, pH and temperature not specified in the publication | Plasmodium vivax | |
| 0.1 | - |
3-butyl-6-methoxy-2-methyl-4-[(2-phenylethyl)sulfanyl]quinoline | above, pH and temperature not specified in the publication | Plasmodium vivax | |
| 0.1 | - |
ethyl 4-[(2-cyanoethyl)amino]quinoline-3-carboxylate | above, pH and temperature not specified in the publication | Plasmodium vivax | |
| 0.1 | - |
ethyl 6-acetyl-4-(but-3-yn-1-ylsulfanyl)quinoline-3-carboxylate | above, pH and temperature not specified in the publication | Plasmodium vivax | |
| 0.1 | - |
ethyl 4-(but-3-yn-1-ylsulfanyl)-6-(1-hydroxyethyl)quinoline-3-carboxylate | above, pH and temperature not specified in the publication | Plasmodium vivax | |
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