Application | Comment | Organism |
---|---|---|
drug development | the enzyme N-myristoyltransferase represents a promising drug target | Trypanosoma brucei |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-acetyl-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-2,3-dihydro-1H-indole-5-sulfonamide | - |
Trypanosoma brucei | |
2,6-dichloro-4-(1,2,3,4-tetrahydroisoquinolin-5-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide | - |
Trypanosoma brucei | |
2,6-dichloro-4-(2-piperazin-1-ylpyridin-4-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-benzenesulfonamide | - |
Trypanosoma brucei | |
2,6-dichloro-4-(isoquinolin-5-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide | - |
Trypanosoma brucei | |
2,6-dichloro-4-[6-(piperazin-1-yl)pyridin-3-yl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide | - |
Trypanosoma brucei | |
2,6-dichloro-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide | - |
Trypanosoma brucei | |
2-oxo-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydroquinoline-6-sulfonamide | - |
Trypanosoma brucei | |
3',5'-dichloro-4'-[(1,3,5-trimethyl-1H-pyrazol-4-yl)sulfamoyl]biphenyl-3-carboxamide | - |
Trypanosoma brucei | |
3,5-dichloro-3'-[(4-methylpiperazin-1-yl)methyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)biphenyl-4-sulfonamide | - |
Trypanosoma brucei | |
3,5-dichloro-3'-[(diethylamino)methyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)biphenyl-4-sulfonamide | - |
Trypanosoma brucei | |
3,5-dichloro-4'-[(4-methylpiperazin-1-yl)methyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)biphenyl-4-sulfonamide | - |
Trypanosoma brucei | |
3,5-dichloro-4'-[(diethylamino)methyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)biphenyl-4-sulfonamide | - |
Trypanosoma brucei | |
3-cyano-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide | - |
Trypanosoma brucei | |
4-(1H-pyrazol-1-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide | - |
Trypanosoma brucei | |
4-bromo-2,6-dichloro-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-benzenesulfonamide | - |
Trypanosoma brucei | |
4-bromo-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzamide | - |
Trypanosoma brucei | |
4-bromo-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide | - |
Trypanosoma brucei | |
4-bromo-N-(2-methylpropyl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzamide | - |
Trypanosoma brucei | |
4-bromo-N-methyl-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide | - |
Trypanosoma brucei | |
4-bromo-N-[(1,3,5-trimethyl-1H-pyrazol-4-yl)methyl]benzenesulfonamide | - |
Trypanosoma brucei | |
4-cyano-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide | - |
Trypanosoma brucei | |
4-methoxy-2,3,6-trimethyl-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide | - |
Trypanosoma brucei | |
4-methoxy-2,3,6-trimethyl-N-(1H-pyrazol-3-yl)benzenesulfonamide | - |
Trypanosoma brucei | |
4-methoxy-2,3,6-trimethyl-N-(2-methylpyridin-3-yl)benzenesulfonamide | - |
Trypanosoma brucei | |
4-methoxy-2,3,6-trimethyl-N-(pyridin-3-yl)benzenesulfonamide | - |
Trypanosoma brucei | |
4-methoxy-2,3,6-trimethyl-N-phenylbenzenesulfonamide | - |
Trypanosoma brucei | |
4-methoxy-2,3,6-trimethyl-N-[(1,3,5-trimethyl-1H-pyrazol-4-yl)methyl]benzenesulfonamide | - |
Trypanosoma brucei | |
4-[(4-bromophenoxy)methyl]-1,3,5-trimethyl-1H-pyrazole | - |
Trypanosoma brucei | |
4-[[(4-bromophenyl)sulfonyl]methyl]-1,3,5-trimethyl-1H-pyrazole | - |
Trypanosoma brucei | |
6-(2-methyl-1,3-thiazol-4-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide | - |
Trypanosoma brucei | |
6-(benzylamino)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide | - |
Trypanosoma brucei | |
6-(morpholin-4-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide | - |
Trypanosoma brucei | |
6-([2-[4-(propan-2-yl)piperazin-1-yl]ethyl]amino)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide | - |
Trypanosoma brucei | |
6-chloro-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide | - |
Trypanosoma brucei | |
6-[(1H-indol-5-ylmethyl)amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide | - |
Trypanosoma brucei | |
6-[2-(4-methylpiperazin-1-yl)ethylamino]pyridine-3-sulfonic acid (1,3,5-trimethyl-1H-pyrazol-4-yl)amide | - |
Trypanosoma brucei | |
6-[3-(piperazin-1-yl)piperidin-1-yl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide | - |
Trypanosoma brucei | |
6-[3-(piperazin-1-yl)pyrrolidin-1-yl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide | - |
Trypanosoma brucei | |
6-[[2-(1-methylpiperidin-4-yl)ethyl]amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide | - |
Trypanosoma brucei | |
6-[[2-(1H-imidazol-1-yl)ethyl]amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide | - |
Trypanosoma brucei | |
6-[[2-(4-benzylpiperazin-1-yl)ethyl]amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide | - |
Trypanosoma brucei | |
6-[[2-(4-methylpiperazin-1-yl)ethyl]amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide | - |
Trypanosoma brucei | |
6-[[2-(4-phenylpiperazin-1-yl)ethyl]amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide | - |
Trypanosoma brucei | |
6-[[2-(morpholin-4-yl)ethyl]amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide | - |
Trypanosoma brucei | |
6-[[2-(piperazin-1-yl)ethyl]amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide | - |
Trypanosoma brucei | |
6-[[2-(piperidin-1-yl)ethyl]amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide | - |
Trypanosoma brucei | |
6-[[3-(dimethylamino)propyl]amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide | - |
Trypanosoma brucei | |
6-[[4-[(dimethylamino)methyl]benzyl](methyl)amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide | - |
Trypanosoma brucei | |
DDD85646 | - |
Homo sapiens | |
DDD85646 | - |
Trypanosoma brucei | |
N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide | - |
Trypanosoma brucei | |
N-(1-propyl-3,5-dimethyl-1H-pyrazol-4-yl)-4-methoxy-2,3,6-trimethylbenzenesulfonamide | - |
Trypanosoma brucei | |
N-(3,4-dimethyl-1,2-oxazol-5-yl)-4-methoxy-2,3,6-trimethylbenzenesulfonamide | - |
Trypanosoma brucei | |
N-(3,5-dimethyl-1,2-oxazol-4-yl)-4-methoxy-2,3,6-trimethylbenzenesulfonamide | - |
Trypanosoma brucei | |
N-(3,5-dimethyl-1-propyl-1H-pyrazol-4-yl)-4-methoxy-2,3,6-trimethylbenzenesulfonamide | - |
Trypanosoma brucei | |
N-(3,5-dimethyl-1H-pyrazol-4-yl)-4-methoxy-2,3,6-trimethylbenzenesulfonamide | - |
Trypanosoma brucei | |
N-(4-bromobenzyl)-1,3,5-trimethyl-1H-pyrazol-4-amine | - |
Trypanosoma brucei | |
N-(4-bromophenyl)-1,3,5-trimethyl-1H-pyrazole-4-carboxamide | - |
Trypanosoma brucei | |
N-(4-bromophenyl)-1,3,5-trimethyl-1H-pyrazole-4-sulfonamide | - |
Trypanosoma brucei | |
N-(imidazo[1,2-a]pyridin-3-yl)-4-methoxy-2,3,6-trimethylbenzenesulfonamide | - |
Trypanosoma brucei | |
N-benzyl-4-methoxy-2,3,6-trimethylbenzenesulfonamide | - |
Trypanosoma brucei | |
N-[1,3-dimethyl-5-(morpholin-4-yl)-1H-pyrazol-4-yl]-4-methoxy-2,3,6-trimethylbenzenesulfonamide | - |
Trypanosoma brucei | |
N-[4-[(1,3,5-trimethyl-1H-pyrazol-4-yl)sulfamoyl]phenyl]acetamide | - |
Trypanosoma brucei | |
tert-butyl 4-[2-([5-[(1,3,5-trimethyl-1H-pyrazol-4-yl)sulfamoyl]pyridin-2-yl]amino)ethyl]piperazine-1-carboxylate | - |
Trypanosoma brucei |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozyme NMT-1 | - |
Trypanosoma brucei | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
myristoyl-CoA + peptide CAP5.5 | N-myristoylation of the synthetic peptide CAP5.5, derived from the N-terminus of the Trypanosoma brucei CAP5.5 protein | Homo sapiens | CoA + N-myristoyl-peptide CAP5.5 | - |
? | |
myristoyl-CoA + peptide CAP5.5 | N-myristoylation of the synthetic peptide CAP5.5, derived from the N-terminus of the Trypanosoma brucei CAP5.5 protein | Trypanosoma brucei | CoA + N-myristoyl-peptide CAP5.5 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
N-myristoyltransferase | - |
Homo sapiens |
N-myristoyltransferase | - |
Trypanosoma brucei |
NMT | - |
Trypanosoma brucei |
NMT-1 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
22 | - |
assay at room temperature | Homo sapiens |
22 | - |
assay at room temperature | Trypanosoma brucei |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
7.4 | - |
assay at | Trypanosoma brucei |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000002 | - |
pH 7.4, 22°C | Trypanosoma brucei | 2,6-dichloro-4-(2-piperazin-1-ylpyridin-4-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-benzenesulfonamide | |
0.000005 | - |
pH 7.4, 22°C | Trypanosoma brucei | 3,5-dichloro-3'-[(4-methylpiperazin-1-yl)methyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)biphenyl-4-sulfonamide | |
0.00002 | - |
pH 7.4, 22°C | Trypanosoma brucei | 3,5-dichloro-3'-[(diethylamino)methyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)biphenyl-4-sulfonamide | |
0.00003 | - |
pH 7.4, 22°C | Trypanosoma brucei | 6-[3-(piperazin-1-yl)piperidin-1-yl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide | |
0.00003 | - |
pH 7.4, 22°C | Trypanosoma brucei | 6-[[2-(1-methylpiperidin-4-yl)ethyl]amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide | |
0.000034 | - |
pH 7.4, 22°C | Trypanosoma brucei | 4-bromo-2,6-dichloro-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-benzenesulfonamide | |
0.00011 | - |
pH 7.4, 22°C | Trypanosoma brucei | 6-[3-(piperazin-1-yl)pyrrolidin-1-yl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide | |
0.00011 | - |
pH 7.4, 22°C | Trypanosoma brucei | 6-[[2-(4-methylpiperazin-1-yl)ethyl]amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide | |
0.00014 | - |
pH 7.4, 22°C | Trypanosoma brucei | 6-[2-(4-methylpiperazin-1-yl)ethylamino]pyridine-3-sulfonic acid (1,3,5-trimethyl-1H-pyrazol-4-yl)amide | |
0.00029 | - |
pH 7.4, 22°C | Trypanosoma brucei | 2,6-dichloro-4-[6-(piperazin-1-yl)pyridin-3-yl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide | |
0.00033 | - |
pH 7.4, 22°C | Trypanosoma brucei | 6-[(1H-indol-5-ylmethyl)amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide | |
0.00036 | - |
pH 7.4, 22°C | Trypanosoma brucei | 6-[[4-[(dimethylamino)methyl]benzyl](methyl)amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide | |
0.0009 | - |
pH 7.4, 22°C | Trypanosoma brucei | 3',5'-dichloro-4'-[(1,3,5-trimethyl-1H-pyrazol-4-yl)sulfamoyl]biphenyl-3-carboxamide | |
0.001 | - |
pH 7.4, 22°C | Trypanosoma brucei | 6-[[2-(4-phenylpiperazin-1-yl)ethyl]amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide | |
0.001 | - |
pH 7.4, 22°C | Trypanosoma brucei | 6-[[2-(piperazin-1-yl)ethyl]amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide | |
0.001 | - |
pH 7.4, 22°C | Trypanosoma brucei | 6-([2-[4-(propan-2-yl)piperazin-1-yl]ethyl]amino)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide | |
0.001 | - |
pH 7.4, 22°C | Trypanosoma brucei | 2,6-dichloro-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide | |
0.0012 | - |
pH 7.4, 22°C | Trypanosoma brucei | 3,5-dichloro-4'-[(4-methylpiperazin-1-yl)methyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)biphenyl-4-sulfonamide | |
0.0013 | - |
pH 7.4, 22°C | Trypanosoma brucei | 6-[[2-(1H-imidazol-1-yl)ethyl]amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide | |
0.0013 | - |
pH 7.4, 22°C | Trypanosoma brucei | 6-(benzylamino)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide | |
0.0019 | - |
pH 7.4, 22°C | Trypanosoma brucei | 6-(morpholin-4-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide | |
0.0021 | - |
pH 7.4, 22°C | Trypanosoma brucei | 6-[[3-(dimethylamino)propyl]amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide | |
0.0028 | - |
pH 7.4, 22°C | Trypanosoma brucei | N-[4-[(1,3,5-trimethyl-1H-pyrazol-4-yl)sulfamoyl]phenyl]acetamide | |
0.0033 | - |
pH 7.4, 22°C | Trypanosoma brucei | 2-oxo-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydroquinoline-6-sulfonamide | |
0.0043 | - |
pH 7.4, 22°C | Trypanosoma brucei | 2,6-dichloro-4-(1,2,3,4-tetrahydroisoquinolin-5-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide | |
0.0048 | - |
pH 7.4, 22°C | Trypanosoma brucei | 4-(1H-pyrazol-1-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide | |
0.0086 | - |
pH 7.4, 22°C | Trypanosoma brucei | 1-acetyl-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-2,3-dihydro-1H-indole-5-sulfonamide | |
0.01 | - |
pH 7.4, 22°C | Trypanosoma brucei | 6-[[2-(4-benzylpiperazin-1-yl)ethyl]amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide | |
0.01 | - |
pH 7.4, 22°C | Trypanosoma brucei | tert-butyl 4-[2-([5-[(1,3,5-trimethyl-1H-pyrazol-4-yl)sulfamoyl]pyridin-2-yl]amino)ethyl]piperazine-1-carboxylate | |
0.011 | - |
pH 7.4, 22°C | Trypanosoma brucei | 3,5-dichloro-4'-[(diethylamino)methyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)biphenyl-4-sulfonamide | |
0.012 | - |
pH 7.4, 22°C | Trypanosoma brucei | 6-(2-methyl-1,3-thiazol-4-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide | |
0.012 | - |
pH 7.4, 22°C | Trypanosoma brucei | N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide | |
0.014 | - |
pH 7.4, 22°C | Trypanosoma brucei | 6-[[2-(piperidin-1-yl)ethyl]amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide | |
0.026 | - |
pH 7.4, 22°C | Trypanosoma brucei | 6-chloro-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide | |
0.028 | - |
pH 7.4, 22°C | Trypanosoma brucei | 3-cyano-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide | |
0.032 | - |
pH 7.4, 22°C | Trypanosoma brucei | 4-cyano-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide | |
0.038 | - |
pH 7.4, 22°C | Trypanosoma brucei | 6-[[2-(morpholin-4-yl)ethyl]amino]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridine-3-sulfonamide | |
0.042 | - |
pH 7.4, 22°C | Trypanosoma brucei | 4-[[(4-bromophenyl)sulfonyl]methyl]-1,3,5-trimethyl-1H-pyrazole | |
0.049 | - |
pH 7.4, 22°C | Trypanosoma brucei | 2,6-dichloro-4-(isoquinolin-5-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide | |
0.1 | - |
above, pH 7.4, 22°C | Trypanosoma brucei | N-(4-bromophenyl)-1,3,5-trimethyl-1H-pyrazole-4-sulfonamide | |
0.1 | - |
above, pH 7.4, 22°C | Trypanosoma brucei | N-(4-bromobenzyl)-1,3,5-trimethyl-1H-pyrazol-4-amine | |
0.1 | - |
above, pH 7.4, 22°C | Trypanosoma brucei | 4-[(4-bromophenoxy)methyl]-1,3,5-trimethyl-1H-pyrazole | |
0.1 | - |
above, pH 7.4, 22°C | Trypanosoma brucei | 4-bromo-N-[(1,3,5-trimethyl-1H-pyrazol-4-yl)methyl]benzenesulfonamide | |
0.1 | - |
above, pH 7.4, 22°C | Trypanosoma brucei | N-(4-bromophenyl)-1,3,5-trimethyl-1H-pyrazole-4-carboxamide |