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Literature summary for 2.3.1.97 extracted from
- A second mammalian N-myristoyltransferase (1998), J. Biol. Chem., 273, 6595-6598.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| overexpression in COS-7 cell, isoform 1 | Mus musculus |
| overexpression in COS-7 cell, isoform 1 and 2 | Homo sapiens |
| overexpression in COS-7 cell, isoform 2 | Mus musculus |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| additional information | - |
amino acid sequence alignment and comparison, isoforms 1 and 2 | Homo sapiens |
| additional information | - |
amino acid sequence alignment and comparison, isoforms 1 and 2 | Mus musculus |
| 65000 | - |
1 * 65000, isoform 2, SDS-PAGE | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O60551 | isoform NMT-2 | - |
| Homo sapiens | P30419 | isoform NMT-1 | - |
| Mus musculus | O70310 | isoform NMT-1 | - |
| Mus musculus | O70311 | isoform NMT-2 | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.000035 | - |
recombinant enzyme from COS-7 cells | Homo sapiens |
| 0.000039 | - |
recombinant enzyme from COS-7 cells | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| myristoyl-CoA + cAMP-dependent protein kinase-derived peptide | - |
Homo sapiens | N-myristoylated cAMP-dependent protein kinase-derived peptide + CoA | - |
? |  |
| myristoyl-CoA + Gly-Asn-Ala-Ala-Ala-Ala-Arg-Arg | cAMP-dependent protein kinase-derived peptide | Homo sapiens | N-myristoyl-Gly-Asn-Ala-Ala-Ala-Ala-Arg-Arg + CoA | - |
? | |
| myristoyl-CoA + glycylpeptide | - |
Homo sapiens | N-myristoylglycylpeptide + CoA | - |
? | |
| myristoyl-CoA + glycylpeptide | - |
Mus musculus | N-myristoylglycylpeptide + CoA | - |
? | |
| myristoyl-CoA + p60src-derived peptide | decapeptide, best substrate | Homo sapiens | N-myristoylated p60src-derived peptide + CoA | - |
? | |
| myristoyl-CoA + tumor necrosis factor-derived peptide | - |
Homo sapiens | N-myristoylated tumor necrosis factor-derived peptide + CoA | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 65000, isoform 2, SDS-PAGE | Homo sapiens |
| monomer | 1 * 49000-68000, several forms of isoform 1, SDS-PAGE | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| NMT | - |
Homo sapiens |
| NMT | - |
Mus musculus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Homo sapiens |
| 25 | - |
assay at | Mus musculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Homo sapiens |
| 7.5 | - |
assay at | Mus musculus |
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Release 2023.1 (January 2023)
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