Literature summary for 2.3.1.97 extracted from

Paige, L.A.; Zheng, G.Q.; DeFrees, S.A.; Cassady, J.M.; Geahlen, R.L.
Metabolic activation of 2-substituted derivatives of myristic acid to form potent inhibitors of myristoyl CoA:protein N-myristoyltransferase (1990), Biochemistry, 29, 10566-10573.

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Inhibitors

Inhibitors	Comment	Organism	Structure
1-Bromo-2-fluorotetradecane	-	Mus musculus
1-O-Acetyl-2-fluorotetradecane	-	Mus musculus
2-Bromomyristic acid	-	Mus musculus
2-bromomyristoyl-CoA	-	Mus musculus
2-Fluoromyristic acid	-	Mus musculus
2-fluoromyristoyl-CoA	-	Mus musculus
2-Fluorotetradecan-1-ol	-	Mus musculus
2-Hydroxymyristic acid	-	Mus musculus
2-hydroxymyristoyl-CoA	-	Mus musculus
S-(2-Oxo)-pentadecyl-CoA	strong	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
myristoyl-CoA + glycylpeptide	-	Mus musculus	N-myristoylglycylpeptide + CoA	-	?

Synonyms

Synonyms	Comment	Organism
NMT	-	Mus musculus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.8	-	assay at	Mus musculus

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.045	-	2-hydroxymyristoyl-CoA	-	Mus musculus
0.1	-	2-Bromomyristic acid	-	Mus musculus
0.2	-	2-Hydroxymyristic acid	-	Mus musculus
0.2	-	2-fluoromyristoyl-CoA	-	Mus musculus
0.45	-	2-bromomyristoyl-CoA	-	Mus musculus

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Release 2023.1 (January 2023)