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Literature summary for 2.3.1.97 extracted from

  • Rudnick, D.A.; Rocque, W.J.; McWherter, C.A.; Toth, M.V.; Jackson-Machelski, E.; Gordon, J.I.
    Use of photoactivatable peptide substrates of Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase (Nmt1p) to characterize a myristoyl-CoA-Nmt1p-peptide ternary complex and to provide evidence for an ordered reaction mechanism (1993), Proc. Natl. Acad. Sci. USA, 90, 1087-1091.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
Ala-Leu-Tyr-Ala-Ser-Lys-Leu-Ser competitve against peptide substrate Gly-Leu-Tyr-Ala-Ser-Lys-Leu-Ser Saccharomyces cerevisiae
S-(2-Oxo)-pentadecyl-CoA
-
 Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.000025
-
 Gly-Asn-Ala-Ala-Ser-Arg-Arg
-
 Saccharomyces cerevisiae
0.00007
-
 Gly-Leu-Tyr-Ala-Ser-Lys-Leu-Ser
-
 Saccharomyces cerevisiae
0.016
-
 Gly-Asn-Ala-Ala-Ala-Ala-Arg-Arg
-
 Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
myristoyl-CoA + protein Saccharomyces cerevisiae overview proteins ?
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
 gene nmt1
-

Reaction

Reaction Comment Organism Reaction ID
tetradecanoyl-CoA + an N-terminal-glycyl-[protein] = CoA + an N-terminal-N-tetradecanoylglycyl-[protein] ordered mechanism Saccharomyces cerevisiae
a
tetradecanoyl-CoA + an N-terminal-glycyl-[protein] = CoA + an N-terminal-N-tetradecanoylglycyl-[protein] peptide binding site Saccharomyces cerevisiae
a

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 assay method Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
myristoyl-CoA + Gly-Asn-Ala-Ala-Ala-Ala-Arg-Arg
-
 Saccharomyces cerevisiae N-myristoyl-Gly-Asn-Ala-Ala-Ala-Ala-Arg-Arg + CoA
-
 ?
myristoyl-CoA + Gly-Asn-Ala-Ala-Ser-Arg-Arg
-
 Saccharomyces cerevisiae N-myristoyl-Gly-Asn-Ala-Ala-Ser-Arg-Arg + CoA
-
 ?
myristoyl-CoA + Gly-Leu-Tyr-Ala-Ser-Lys-Leu-Ser
-
 Saccharomyces cerevisiae N-myristoyl-Gly-Leu-Tyr-Ala-Ser-Lys-Leu-Ser + CoA
-
 ?
myristoyl-CoA + glycylpeptide specific for myristoyl-CoA Saccharomyces cerevisiae N-myristoylglycylpeptide + CoA
-
 ?
myristoyl-CoA + protein overview proteins Saccharomyces cerevisiae ?
-
 ?

Synonyms

Synonyms Comment Organism
Nmt1p
-
 Saccharomyces cerevisiae