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Literature summary for 2.3.1.94 extracted from
- The DEBS paradigm for type I modular polyketide synthases and beyond (2009), Methods Enzymol., 459, 113-142.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| propanoyl-CoA + 6 (2S)-methylmalonyl-CoA + 6 NADPH + 6 H+ | Saccharopolyspora erythraea | - |
6-deoxyerythronolide B + 7 CoA + 6 CO2 + H2O + 6 NADP+ | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharopolyspora erythraea | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| propanoyl-CoA + 6 (2S)-methylmalonyl-CoA + 6 NADPH + 6 H+ | - |
Saccharopolyspora erythraea | 6-deoxyerythronolide B + 7 CoA + 6 CO2 + H2O + 6 NADP+ | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | DEBS is organized into modules comprising of multiple catalytic domains, to assemble short acyl-CoA precursors into complex polyketide products, each module contains minimally three functional domains, a beta-ketosynthase, KS, an acyltransferase, AT, and an acyl carrier protein, ACP | Saccharopolyspora erythraea |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 6-deoxyerythronolide B | - |
Saccharopolyspora erythraea |
| DEBS | - |
Saccharopolyspora erythraea |
| PKS | - |
Saccharopolyspora erythraea |
| polyketide synthase | - |
Saccharopolyspora erythraea |
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