Literature summary for 2.3.1.87 extracted from

Koch, M.; Dehghani, F.; Habazettl, I.; Schomerus, C.; Korf, H.W.
Cannabinoids attenuate norepinephrine-induced melatonin biosynthesis in the rat pineal gland by reducing arylalkylamine N-acetyltransferase activity without involvement of cannabinoid receptors (2006), J. Neurochem., 98, 267-278.

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Inhibitors

Inhibitors	Comment	Organism	Structure
9-carboxy-11-nor-delta-9-tetrahydrocannabinol	significantly reduces norepinephrine-induced arylalkylamine N-acetyltransferase activity	Rattus norvegicus
cannabidiol	significantly reduces norepinephrine-induced arylalkylamine N-acetyltransferase activity	Rattus norvegicus
cannabinoid	cannabinoids inhibit AANAT activity and attenuate melatonin biosynthesis through intracellular actions without involvement of classical cannabinoid receptor-dependent signaling cascades	Rattus norvegicus
cannabinol	significantly reduces norepinephrine-induced arylalkylamine N-acetyltransferase activity	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	Q64666	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
pineal gland	-	Rattus norvegicus	-

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Release 2023.1 (January 2023)