Literature summary for 2.3.1.87 extracted from

Zheng, W.; Schwarzer, D.; Lebeau, A.; Weller, J.L.; Klein, D.C.; Cole, P.A.
Cellular stability of serotonin N-acetyltransferase conferred by phosphonodifluoromethylene alanine (Pfa) substitution for Ser-205 (2005), J. Biol. Chem., 280, 10462-10467.

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Protein Variants

Protein Variants	Comment	Organism
additional information	phosphonodifluoromethylene alanine at Ser-205 is synthesized and fused to bacterially expressed AANAT30199 using expressed protein ligation. The resulting semisynthetic protein has enhanced affinity for the expressed 14-3-3 protein and exhibits greater cellular stability in microinjection experiments, as compared with the unmodified AANAT	Ovis aries

Organism

Organism	UniProt	Comment	Textmining
Ovis aries	Q29495	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-CoA + tryptamine	-	Ovis aries	CoA + N-acetyltryptamine	-	?

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Release 2023.1 (January 2023)