General Stability | Organism |
---|---|
acetyl-CoA stabilizes | Rattus norvegicus |
acetyl-CoA stabilizes | Ovis aries |
ATP stabilizes | Rattus norvegicus |
ATP stabilizes | Ovis aries |
freezing markedly decreases activity | Rattus norvegicus |
freezing markedly decreases activity | Ovis aries |
polyanions stabilize | Rattus norvegicus |
polyanions stabilize | Ovis aries |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Disulfides | in vivo and in vitro, reversible by dithiothreitol | Ovis aries | |
Disulfides | in vivo and in vitro, reversible by dithiothreitol | Rattus norvegicus | |
Peptides containing a disulfide bond | - |
Ovis aries | |
Peptides containing a disulfide bond | - |
Rattus norvegicus | |
Zn2+ | at low concentration | Ovis aries | |
Zn2+ | at low concentration | Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
additional information | activation by salts as a function of ionic strength | Rattus norvegicus | |
additional information | activation by salts as a function of ionic strength | Ovis aries |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Rattus norvegicus |
additional information | - |
multiple forms, from 10000 Da via 39000 Da to 100000 Da | Ovis aries |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + serotonin | Rattus norvegicus | initial reaction in melatonin synthesis from serotonin | CoA + N-acetylserotonin | - |
? | |
acetyl-CoA + serotonin | Ovis aries | initial reaction in melatonin synthesis from serotonin | CoA + N-acetylserotonin | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Ovis aries | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
affinity chromatography on Sepharose CoA | Ovis aries |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
pineal gland | - |
Rattus norvegicus | - |
pineal gland | - |
Ovis aries | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.000195 | - |
- |
Ovis aries |
Storage Stability | Organism |
---|---|
0-2°C, up to 72 h | Rattus norvegicus |
0-2°C, up to 72 h | Ovis aries |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + beta-phenylethylamine | - |
Rattus norvegicus | CoA + N-(2-phenylethyl)-acetaminde | - |
? | |
acetyl-CoA + beta-phenylethylamine | - |
Ovis aries | CoA + N-(2-phenylethyl)-acetaminde | - |
? | |
acetyl-CoA + serotonin | i.e. 5-hydroxytryptamine | Rattus norvegicus | CoA + N-acetylserotonin | - |
? | |
acetyl-CoA + serotonin | i.e. 5-hydroxytryptamine | Ovis aries | CoA + N-acetylserotonin | - |
? | |
acetyl-CoA + serotonin | initial reaction in melatonin synthesis from serotonin | Rattus norvegicus | CoA + N-acetylserotonin | - |
? | |
acetyl-CoA + serotonin | initial reaction in melatonin synthesis from serotonin | Ovis aries | CoA + N-acetylserotonin | - |
? | |
acetyl-CoA + tryptamine | - |
Rattus norvegicus | CoA + N-acetyltryptamine | - |
? | |
acetyl-CoA + tryptamine | - |
Ovis aries | CoA + N-acetyltryptamine | - |
? | |
additional information | arylamines, such as aniline or p-phenetidine are very poor substrates | Rattus norvegicus | ? | - |
? | |
additional information | arylamines, such as aniline or p-phenetidine are very poor substrates | Ovis aries | ? | - |
? |