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Literature summary for 2.3.1.86 extracted from

  • Dittrich, F.; Zajonc, D.; Huhne, K.; Hoja, U.; Ekici, A.; Greiner, E.; Klein, H.; Hofmann, J.; Bessoule, J.J.; Sperling, P.; Schweizer, E.
    Fatty acid elongation in yeast. Biochemical characteristics of the enzyme system and isolation of elongation-defective mutants (1998), Eur. J. Biochem., 252, 477-485.
    View publication on PubMed
Search for more literature for 2.3.1.86

Activating Compound

Activating Compound Comment Organism Structure
ATP stimulatory at suboptimal but not at saturating substrate concentrations Saccharomyces cerevisiae

Cloned(Commentary)

Cloned (Comment) Organism
-
 Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.05
-
 lauroyl-CoA
-
 Saccharomyces cerevisiae
0.13
-
 palmitoyl-CoA
-
 Saccharomyces cerevisiae
0.33
-
 octanoyl-CoA
-
 Saccharomyces cerevisiae
0.4
-
 myristoyl-CoA
-
 Saccharomyces cerevisiae
0.83
-
 decanoyl-CoA
-
 Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
 mutants lacking endogenous de novo fatty acid synthesis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + 7 malonyl-CoA + 7 NADH + 7 NADPH + 14 H+ mutants require acyl-CoA primers of 10 or more carbon atoms, maximal activity with 12-14 carbon atoms Saccharomyces cerevisiae palmitoyl-CoA + 7 CoA + 7 CO2 + 7 NAD+ + 7 NADP+ + 7 H2O
-
 ?
acetyl-CoA + 7 malonyl-CoA + 7 NADH + 7 NADPH + 14 H+ mutants require acyl-CoA primers of 10 or more carbon atoms, maximal activity with 12-14 carbon atoms Saccharomyces cerevisiae X2180-1A palmitoyl-CoA + 7 CoA + 7 CO2 + 7 NAD+ + 7 NADP+ + 7 H2O
-
 ?
decanoyl-CoA + malonyl-CoA + NADPH + H+
-
 Saccharomyces cerevisiae ?
-
 ?
lauroyl-CoA + malonyl-CoA + NADPH + H+
-
 Saccharomyces cerevisiae ?
-
 ?
myristoyl-CoA + malonyl-CoA + NADPH + H+
-
 Saccharomyces cerevisiae ?
-
 ?
octanoyl-CoA + malonyl-CoA + NADPH + H+
-
 Saccharomyces cerevisiae ?
-
 ?

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Saccharomyces cerevisiae