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Literature summary for 2.3.1.86 extracted from

  • Stoops, J.K.; Wakil, S.J.
    Yeast fatty acid synthetase: structure-function relationship and nature of the beta-ketoacyl synthetase site (1980), Proc. Natl. Acad. Sci. USA, 77, 4544-4548.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
1,3-Dibromo-2-propanone complete inhibition at 0.005 mM after 1 min, cross-links alpha-, not beta-subunits, inhibits only beta-ketoacyl synthetase reaction, acetyl-CoA prevents, malonyl-CoA prevents only slightly Saccharomyces cerevisiae
iodoacetamide irreversible Saccharomyces cerevisiae

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
additional information
-
 MW of components Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Reaction

Reaction Comment Organism Reaction ID
acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H+ = long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP+ structure Saccharomyces cerevisiae
a
acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H+ = long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP+ reaction mechanism Saccharomyces cerevisiae
a

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3
-
-
 Saccharomyces cerevisiae

Subunits

Subunits Comment Organism
additional information multifunctional subunits Saccharomyces cerevisiae

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Saccharomyces cerevisiae