Cloned (Comment) | Organism |
---|---|
transformation technique, plasmid YEpFAS2 transformed to and expressed in Escherichia coli maxi-cells | Saccharomyces cerevisiae |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,3-Dibromo-2-propanone | - |
Saccharomyces cerevisiae |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Mycolicibacterium smegmatis |
additional information | - |
alpha6beta6-complex of multifunctional subunits | Saccharomyces cerevisiae |
additional information | - |
amino acid sequence of acyl-carrier-protein | Saccharomyces cerevisiae |
180000 | - |
alpha6,beta6, 6 * 185000 + 6 * 180000, SDS-PAGE | Saccharomyces cerevisiae |
185000 | - |
alpha6,beta6, 6 * 185000 + 6 * 180000, SDS-PAGE | Saccharomyces cerevisiae |
203000 | - |
alpha6,beta6, 6 * 213000 + 6 * 203000, Tris-glycine-SDS-PAGE | Saccharomyces cerevisiae |
213000 | - |
alpha6,beta6, 6 * 213000 + 6 * 203000, Tris-glycine-SDS-PAGE | Saccharomyces cerevisiae |
2400000 | - |
sedimentation velocity | Saccharomyces cerevisiae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + malonyl-CoA + NADH + NADPH | Saccharomyces cerevisiae | multifunctional enzyme involved in yeast fat metabolism | ? | - |
? | |
acetyl-CoA + malonyl-CoA + NADH + NADPH | Mycolicibacterium smegmatis | multifunctional enzyme involved in yeast fat metabolism | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycolicibacterium smegmatis | - |
- |
- |
Saccharomyces cerevisiae | - |
- |
- |
Purification (Comment) | Organism |
---|---|
isolation of alpha- and beta-subunits | Saccharomyces cerevisiae |
isolation of alpha- and beta-subunits by citraconic and dimethylmaleic anhydride modification | Saccharomyces cerevisiae |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ = hexadecanoyl-CoA + 7 CoA + 7 CO2 + 14 NADP+ + 7 H2O | reaction mechanism | Saccharomyces cerevisiae | |
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ = hexadecanoyl-CoA + 7 CoA + 7 CO2 + 14 NADP+ + 7 H2O | reaction mechanism | Mycolicibacterium smegmatis | |
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ = hexadecanoyl-CoA + 7 CoA + 7 CO2 + 14 NADP+ + 7 H2O | structure | Saccharomyces cerevisiae | |
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ = hexadecanoyl-CoA + 7 CoA + 7 CO2 + 14 NADP+ + 7 H2O | structure and regulation | Saccharomyces cerevisiae |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + 7 malonyl-CoA + 7 NADH + 7 NADPH + 14 H+ | - |
Mycolicibacterium smegmatis | palmitoyl-CoA + 7 CoA + 7 CO2 + 7 NAD+ + 7 NADP+ + 7 H2O | - |
? | |
acetyl-CoA + 7 malonyl-CoA + 7 NADH + 7 NADPH + 14 H+ | stable multifunctional enzyme complex: carries acetyl-CoA and malonyl-CoA transacylase, beta-ketoacyl reductase, beta-hydroxyacyl dehydrase activities on beta-subunits and condensing enzyme, i.e. beta-ketoacyl synthetase, enoylacyl reductase activities and acyl-carrier-protein components on alpha-subunits | Saccharomyces cerevisiae | palmitoyl-CoA + 7 CoA + 7 CO2 + 7 NAD+ + 7 NADP+ + 7 H2O | - |
? | |
acetyl-CoA + malonyl-CoA + NADH + NADPH | multifunctional enzyme involved in yeast fat metabolism | Saccharomyces cerevisiae | ? | - |
? | |
acetyl-CoA + malonyl-CoA + NADH + NADPH | multifunctional enzyme involved in yeast fat metabolism | Mycolicibacterium smegmatis | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dodecamer | alpha6,beta6, 6 * 185000 + 6 * 180000, SDS-PAGE | Saccharomyces cerevisiae |
dodecamer | alpha6,beta6, 6 * 213000 + 6 * 203000, Tris-glycine-SDS-PAGE | Saccharomyces cerevisiae |
More | - |
Saccharomyces cerevisiae |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
4'-phosphopantetheine | 4.0-5.0 mol per mol enzyme or about 1 mol per 2 subunits | Saccharomyces cerevisiae | |
4'-phosphopantetheine | 4.0-5.0 mol per mol enzyme | Saccharomyces cerevisiae | |
4'-phosphopantetheine | alpha-subunit bears prosthetic group | Saccharomyces cerevisiae | |
FMN | requirement, enoyl reductase activity, associated with beta-subunit, 6 mol per mol synthetase | Saccharomyces cerevisiae | |
NADPH | requirement | Saccharomyces cerevisiae | |
NADPH | requirement | Mycolicibacterium smegmatis |