Literature summary for 2.3.1.85 extracted from

Wang, Y.; Zhang, S.Y.; Ma, X.F.; Tian, W.X.
Potent inhibition of fatty acid synthase by parasitic loranthus [Taxillus chinensis (dc.) danser] and its constituent avicularin (2006), J. Enzyme Inhib. Med. Chem., 21, 87-93.

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Inhibitors

Inhibitors	Comment	Organism	Structure
avicularin	IC50: 0.00615 mM	Anas platyrhynchos
hyperoside	IC50: 0.0746 mM	Anas platyrhynchos
isoquercitrin	IC50: 0.108 mM	Anas platyrhynchos
additional information	FAS is potently inhibited by extracts of Taxillus chinensis Danser. Potent, reversible and a fast irreversible inhibition. IC50: 480 ng/ml	Anas platyrhynchos
quercitrin	IC50: 0.0456 mM	Anas platyrhynchos

Organism

Organism	UniProt	Comment	Textmining
Anas platyrhynchos	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Anas platyrhynchos	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+	-	Anas platyrhynchos	palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O	-	?

Cofactor

Cofactor	Comment	Organism	Structure
NADPH	-	Anas platyrhynchos

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00615	-	IC50: 0.00615 mM	Anas platyrhynchos	avicularin
0.0456	-	IC50: 0.0456 mM	Anas platyrhynchos	quercitrin
0.0746	-	IC50: 0.0746 mM	Anas platyrhynchos	hyperoside
0.108	-	IC50: 0.108 mM	Anas platyrhynchos	isoquercitrin

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Release 2023.1 (January 2023)