Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | 80% loss of activity at 0.008 mM, interacts with SH groups, substrates of the reaction protect, malonyl-CoA being the most effective, addition of dithiothreitol leads to a recovery of 70% enzyme activity; below 0.004 mM, rapid and irreversible inactivation, above 0.004 mM, cross-linking of enzyme involving phosphopantheine SH group. All three substrates, acetyl-CoA, malonyl-CoA, NADPH, protect. Renaturation by dithiothreitol | Gallus gallus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
270000 | - |
subunit, SDS-PAGE | Gallus gallus |
400000 | - |
value above 400000 Da, polymer, SDS-PAGE | Gallus gallus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ | Gallus gallus | participates in energy metabolism in vivo which is related to adiposis and cancer | palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Gallus gallus | - |
- |
- |
Renatured (Comment) | Organism |
---|---|
complete renaturation of enzyme inactivated by Zn2+ using dithiothreitol | Gallus gallus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Gallus gallus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ | - |
Gallus gallus | palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O | - |
? | |
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ | participates in energy metabolism in vivo which is related to adiposis and cancer | Gallus gallus | palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O | - |
? |