Literature summary for 2.3.1.85 extracted from

Podack, E.R.; Saathoff, G.; Seubert, W.
On the mechanism and control of the malonyl-CoA-dependent chain elongation of fatty acids. The malonyl-transfer reaction (1974), Eur. J. Biochem., 50, 237-243.

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Inhibitors

Inhibitors	Comment	Organism	Structure
2,3-trans-octenoyl-CoA	competitively inhibits malonyl-transferase reaction	Rattus norvegicus
3-oxooctanoyl-CoA	competitively inhibits malonyl-transferase reaction	Rattus norvegicus
CoA	competitive inhibition	Rattus norvegicus
iodoacetamide	inhibition of elongation processs	Rattus norvegicus
long-chain acyl-CoA	malonyl-transferase reaction	Rattus norvegicus
Malonyl pantetheine	malonyl-transferase reaction	Rattus norvegicus
malonyl-CoA	competitive, malonyl-transferase reaction	Rattus norvegicus
N-ethylmaleimide	inhibition of elongation process and malonyl transfer at 10 mM	Rattus norvegicus
octanoyl-CoA	competitively inhibits malonyl-transferase reaction	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
microsome	-	Rattus norvegicus	-	-

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Rattus norvegicus

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Rattus norvegicus	-

Cofactor

Cofactor	Comment	Organism	Structure
4'-phosphopantetheine	-	Rattus norvegicus

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.02	-	CoA	-	Rattus norvegicus
1.04	-	Malonyl pantetheine	-	Rattus norvegicus

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Release 2023.1 (January 2023)