Protein Variants | Comment | Organism |
---|---|---|
F171G | the mutant enzyme is unable to confer resistance against amikacin, kanamycin, netilmicin and tobramicin | Klebsiella pneumoniae |
F171I | the mutant enzyme shows reduced resistance against amikacin, kanamycin, netilmicin and tobramicin | Klebsiella pneumoniae |
F171K | the mutant enzyme is unable to confer resistance against amikacin, kanamycin, netilmicin and tobramicin | Klebsiella pneumoniae |
F171L | the mutant enzyme shows reduced resistance against amikacin, kanamycin, netilmicin and tobramicin | Klebsiella pneumoniae |
F171M | the mutant enzyme is able to confer detectable resistance against amikacin, kanamycin, netilmicin and tobramicin, although the levels are considerably lower than those conferred by the wild-type enzyme | Klebsiella pneumoniae |
F171N | the mutant enzyme is unable to confer resistance against amikacin, kanamycin, netilmicin and tobramicin | Klebsiella pneumoniae |
F171S | the mutant enzyme is unable to confer resistance against amikacin, kanamycin, netilmicin and tobramicin | Klebsiella pneumoniae |
F171W | the mutant enzyme is able to confer detectable resistance against amikacin, kanamycin, netilmicin and tobramicin, although the levels are considerably lower than those conferred by the wild-type enzyme | Klebsiella pneumoniae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Klebsiella pneumoniae | involved in resistance to antibiotics | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Klebsiella pneumoniae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + amikacin | wild-type enzyme shows activity, mutant enzymes show no activity or reduced activity | Klebsiella pneumoniae | CoA + N6'-acetylamikacin | - |
? | |
acetyl-CoA + kanamycin | wild-type enzyme shows activity, mutant enzymes show no activity or reduced activity | Klebsiella pneumoniae | CoA + N6'-acetylkanamycin | - |
? | |
acetyl-CoA + netilmicin | wild-type enzyme shows activity, mutant enzymes show no activity or reduced activity | Klebsiella pneumoniae | CoA + N6'-acetylnetilmicin | - |
? | |
acetyl-CoA + tobramycin | wild-type enzyme shows activity, mutant enzymes show no activity or reduced activity | Klebsiella pneumoniae | CoA + N6'-acetyltobramycin | - |
? | |
additional information | involved in resistance to antibiotics | Klebsiella pneumoniae | ? | - |
? |