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Literature summary for 2.3.1.82 extracted from

  • Culebras, E.; Martinez, J.L.; Baquero, F.; Perez-Diaz, J.C.
    pH Modulation of aminoglycoside resistance in Staphylococcus epidermidis harboring 6'-N-aminoglycoside acetyltransferase (1996), J. Antimicrob. Chemother., 37, 881-889.
    View publication on PubMed
Search for more literature for 2.3.1.82

Inhibitors

Inhibitors Comment Organism Structure
amikacin substrate inhibition Staphylococcus epidermidis
gentamicin substrate inhibition Staphylococcus epidermidis
netilmicin substrate inhibition Staphylococcus epidermidis
tobramycin substrate inhibition Staphylococcus epidermidis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.026
-
 tobramycin pH 7.5, 37°C Staphylococcus epidermidis
0.036
-
 amikacin pH 7.5, 37°C Staphylococcus epidermidis
0.077
-
 gentamicin pH 7.5, 37°C Staphylococcus epidermidis
0.077
-
 tobramycin pH 6.5, 37°C Staphylococcus epidermidis
0.216
-
 tobramicin pH 5.5, 37°C Staphylococcus epidermidis
0.259
-
 netilmicin pH 7.5, 37°C Staphylococcus epidermidis
0.297
-
 gentamicin pH 6.5, 37°C Staphylococcus epidermidis
0.364
-
 amikacin pH 6.5, 37°C Staphylococcus epidermidis
0.571
-
 amikacin pH 5.5, 37°C Staphylococcus epidermidis
0.653
-
 gentamicin pH 5.5, 37°C Staphylococcus epidermidis
2.44
-
 netilmicin pH 6.5, 37°C Staphylococcus epidermidis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Staphylococcus epidermidis involved in resistance to antibiotics ?
-
 ?
additional information Staphylococcus epidermidis RYC 13036 involved in resistance to antibiotics ?
-
 ?

Organism

Organism UniProt Comment Textmining
Staphylococcus epidermidis
-
 RYC 13036
-
Staphylococcus epidermidis RYC 13036
-
 RYC 13036
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + amikacin
-
 Staphylococcus epidermidis CoA + N6'-acetylamikacin
-
 ?
acetyl-CoA + amikacin
-
 Staphylococcus epidermidis RYC 13036 CoA + N6'-acetylamikacin
-
 ?
acetyl-CoA + gentamicin
-
 Staphylococcus epidermidis CoA + N6'-acetylgentamicin
-
 ?
acetyl-CoA + gentamicin
-
 Staphylococcus epidermidis RYC 13036 CoA + N6'-acetylgentamicin
-
 ?
acetyl-CoA + gentamicin C
-
 Staphylococcus epidermidis CoA + N6'-acetylgentamicin C
-
 ?
acetyl-CoA + gentamicin C
-
 Staphylococcus epidermidis RYC 13036 CoA + N6'-acetylgentamicin C
-
 ?
acetyl-CoA + netilmicin
-
 Staphylococcus epidermidis CoA + N6'-acetylnetilmicin
-
 ?
acetyl-CoA + tobramycin
-
 Staphylococcus epidermidis CoA + N6'-acetyltobramycin
-
 ?
acetyl-CoA + tobramycin
-
 Staphylococcus epidermidis RYC 13036 CoA + N6'-acetyltobramycin
-
 ?
additional information involved in resistance to antibiotics Staphylococcus epidermidis ?
-
 ?
additional information involved in resistance to antibiotics Staphylococcus epidermidis RYC 13036 ?
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
 reaction with tobramycin, amikacin or gentamicin Staphylococcus epidermidis
7.5
-
 activity with netilmicin Staphylococcus epidermidis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00059
-
 tobramycin pH 7.5, 37°C, substrate inhibition Staphylococcus epidermidis
0.0023
-
 tobramycin pH 6.5, 37°C, substrate inhibition Staphylococcus epidermidis
0.00499
-
 amikacin pH 7.5, 37°C, substrate inhibition Staphylococcus epidermidis
0.00647
-
 tobramycin pH 5.5, 37°C, substrate inhibition Staphylococcus epidermidis
0.0087
-
 amikacin pH 6.5, 37°C, substrate inhibition Staphylococcus epidermidis
0.02206
-
 amikacin pH 5.5, 37°C, substrate inhibition Staphylococcus epidermidis
0.02256
-
 gentamicin pH 5.5, 37°C, substrate inhibition Staphylococcus epidermidis
0.0482
-
 gentamicin pH 6.5, 37°C, substrate inhibition Staphylococcus epidermidis
0.06446
-
 netilmicin pH 5.5, 37°C, substrate inhibition Staphylococcus epidermidis
0.075
-
 netilmicin pH 6.5, 37°C, substrate inhibition Staphylococcus epidermidis
0.079
-
 gentamicin pH 7.5, 37°C, substrate inhibition Staphylococcus epidermidis
0.168
-
 netilmicin pH 7.5, 37°C, substrate inhibition Staphylococcus epidermidis