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Literature summary for 2.3.1.81 extracted from

  • Davies, J.; O'Connor, S.
    Enzymatic modification of aminoglycoside antibiotics: 3-N-acetyltransferase with broad specificity that determines resistance to the novel aminoglycoside apramycin (1978), Antimicrob. Agents Chemother., 14, 69-72.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine studies on the novel aminoglycoside antibiotic apramycin Escherichia coli
medicine studies on the novel aminoglycoside antibiotic apramycin Klebsiella pneumoniae
medicine studies on the novel aminoglycoside antibiotic apramycin Arizona sp.

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli K802N by mating Klebsiella pneumoniae
expression in Escherichia coli K802N by mating Arizona sp.

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
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 Escherichia coli
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soluble
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 Klebsiella pneumoniae
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soluble
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 Arizona sp.
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Organism

Organism UniProt Comment Textmining
Arizona sp.
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Escherichia coli
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 strains K802N, W677, p75-24, S3035, JR225, JR226, JR227
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Klebsiella pneumoniae
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + apramycin a wide range of antibiotics containing the 2-deoxystreptamine ring can act as acceptors, including gentamicin, kanamycin, tobramycin, neomycin Escherichia coli CoA + N3'-acetylapramycin
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 ?
acetyl-CoA + apramycin a wide range of antibiotics containing the 2-deoxystreptamine ring can act as acceptors, including gentamicin, kanamycin, tobramycin, neomycin Klebsiella pneumoniae CoA + N3'-acetylapramycin
-
 ?
acetyl-CoA + apramycin a wide range of antibiotics containing the 2-deoxystreptamine ring can act as acceptors, including gentamicin, kanamycin, tobramycin, neomycin Arizona sp. CoA + N3'-acetylapramycin
-
 ?

Synonyms

Synonyms Comment Organism
3-N-acetyltransferase
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More
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