Inhibitors | Comment | Organism | Structure |
---|---|---|---|
coenzyme A | noncompetitive | Homo sapiens | |
desulfo-CoA | competitive against acetyl-CoA | Homo sapiens | |
N-acetyl-beta-D-glucosamine | competitive against glucosamine; noncompetitive against acetyl-CoA | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0025 | - |
acetyl-CoA | pH 7.0 | Homo sapiens | |
0.003 | - |
beta-D-glucosamine | pH 7.0 | Homo sapiens | |
0.054 | - |
acetyl-CoA | pH 5.0 | Homo sapiens | |
0.37 | - |
beta-D-glucosamine | pH 5.0 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | integral membrane protein | Homo sapiens | 5764 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + heparan sulfate alpha-D-glucosaminide | Homo sapiens | - |
CoA + heparan sulfate N-acetyl-alpha-D-glucosaminide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
partial | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
placenta | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.000673 | - |
lysosomal fraction | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + beta-D-glucosamine | - |
Homo sapiens | CoA + N-acetyl-beta-D-glucosamine | - |
? | |
acetyl-CoA + heparan sulfate alpha-D-glucosaminide | - |
Homo sapiens | CoA + heparan sulfate N-acetyl-alpha-D-glucosaminide | - |
? | |
acetyl-CoA + heparin alpha-D-glucosaminide | also acetylates di- and tetrasaccharide fragments of heparin | Homo sapiens | CoA + heparin N-acetyl-D-glucosamine | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Homo sapiens |
6.5 | - |
tetrasaccharide substrate | Homo sapiens |
6.5 | 8 | mono-and disaccharide substrates | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.032 | - |
coenzyme A | versus acetyl-CoA | Homo sapiens | |
0.082 | - |
coenzyme A | versus beta-D-glucosamine | Homo sapiens | |
0.21 | - |
desulfo-CoA | versus beta-D-glucosamine | Homo sapiens | |
0.22 | - |
desulfo-CoA | versus acetyl-CoA | Homo sapiens | |
3.8 | - |
N-acetyl-beta-D-glucosamine | versus acetyl-CoA | Homo sapiens | |
5.6 | - |
N-acetyl-beta-D-glucosamine | versus glucosamine | Homo sapiens |