Literature summary for 2.3.1.76 extracted from

Shih, M.Y.; Kane, M.A.; Zhou, P.; Yen, C.L.; Streeper, R.S.; Napoli, J.L.; Farese, R.V.
Retinol esterification by DGAT1 is essential for retinoid homeostasis in murine skin (2009), J. Biol. Chem., 284, 4292-4299.

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Application

Application	Comment	Organism
medicine	neutral lipid synthesis enzyme acyl-CoA:diacylglycerol acyltransferase DGAT1 functions as the major acyl-CoA:retinol acyltransferase. When dietary retinol is abundant, DGAT1 deficiency results in elevated levels of retinoic acid in skin and cyclical hair loss, both are prevented by dietary retinol deprivation. DGAT1-deficient skin exhibits enhanced sensitivity to topically administered retinol. Deletion of the enzyme specifically in the epidermis causes alopecia	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
skin	neutral lipid synthesis enzyme acyl-CoA:diacylglycerol acyltransferase 1 functions as the major acyl-CoA:retinol acyltransferase	Mus musculus	-

General Information

General Information	Comment	Organism
physiological function	neutral lipid synthesis enzyme acyl-CoA:diacylglycerol acyltransferase DGAT1 functions as the major acyl-CoA:retinol acyltransferase. When dietary retinol is abundant, DGAT1 deficiency results in elevated levels of retinoic acid in skin and cyclical hair loss, both are prevented by dietary retinol deprivation. DGAT1-deficient skin exhibits enhanced sensitivity to topically administered retinol. Deletion of the enzyme specifically in the epidermis causes alopecia	Mus musculus

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Release 2023.1 (January 2023)