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Literature summary for 2.3.1.76 extracted from
- Assay of lecithin-retinol acyltransferase (1990), Methods Enzymol., 189, 450-459.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | retinyl esterification: storage of vitamin A | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| cellular retinol-binding protein | specific inhibition of retinol fatty-acyltransferase by capturing substrate | Rattus norvegicus | |
| additional information | not inhibited by PMSF | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | membrane fraction | Rattus norvegicus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-CoA + retinol | Rattus norvegicus | - |
CoA + retinyl ester | - |
? |  |
| acyl-CoA + retinol | Rattus norvegicus Sprague-Dawley | - |
CoA + retinyl ester | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
Sprague-Dawley | - |
| Rattus norvegicus Sprague-Dawley | - |
Sprague-Dawley | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial purification by differential centrifugation | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| small intestine | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
activity determined from microsomes | Rattus norvegicus |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -70ºC, phosphate buffer, pH 7.2, DTT, 12 months | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-CoA + retinol | - |
Rattus norvegicus | CoA + retinyl ester | - |
? | |
| acyl-CoA + retinol | - |
Rattus norvegicus Sprague-Dawley | CoA + retinyl ester | - |
? | |
| palmitoyl-CoA + retinol | - |
Rattus norvegicus | CoA + retinylpalmitate | - |
? | |
| palmitoyl-CoA + retinol | - |
Rattus norvegicus Sprague-Dawley | CoA + retinylpalmitate | - |
? | |
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Release 2023.1 (January 2023)
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