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Literature summary for 2.3.1.75 extracted from
- Exploring a Streptomyces wax synthase using acyl-SNACs as donor substrates (2023), RSC Chem. Biol., 4, 742-747.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli BL21 cells | Streptomyces coelicolor |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| L25F | the catalytic efficiency of the mutant is improved toward aromatic, short-linear, and branched acyl-donors compared to the wild type enzyme | Streptomyces coelicolor |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptomyces coelicolor | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| Ni-NTA column chromatography | Streptomyces coelicolor |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + hexanol | - |
Streptomyces coelicolor | hexyl acetate + CoA | - |
? |  |
| S-(2-acetamidoethyl) 2,2-dimethylpropanethioate + butanol | - |
Streptomyces coelicolor | butyl acetate + ? | - |
? | |
| S-(2-acetamidoethyl) 2,2-dimethylpropanethioate + hexanol | - |
Streptomyces coelicolor | hexyl 2,2-dimethylpropanoate + ? | - |
? | |
| S-(2-acetamidoethyl) 2-methylpropanethioate + butanol | - |
Streptomyces coelicolor | butyl butanoate + ? | - |
? | |
| S-(2-acetamidoethyl) 2-methylpropanethioate + hexanol | - |
Streptomyces coelicolor | hexyl 2-methylpropanoate + ? | - |
? | |
| S-(2-acetamidoethyl) benzenecarbothioate + butanol | - |
Streptomyces coelicolor | butyl 2-methylpropanoate + ? | - |
? | |
| S-(2-acetamidoethyl) benzenecarbothioate + hexanol | - |
Streptomyces coelicolor | hexyl benzoate + ? | - |
? | |
| S-(2-acetamidoethyl) butanethioate + butanol | - |
Streptomyces coelicolor | butyl benzoate + ? | - |
? | |
| S-(2-acetamidoethyl) butanethioate + hexanol | - |
Streptomyces coelicolor | hexyl butanoate + ? | - |
? | |
| S-(2-acetamidoethyl) decanethioate + butanol | - |
Streptomyces coelicolor | butyl decanoate + ? | - |
? | |
| S-(2-acetamidoethyl) decanethioate + hexanol | - |
Streptomyces coelicolor | hexyl decanoate + ? | - |
? | |
| S-(2-acetamidoethyl) ethanethioate + butanol | - |
Streptomyces coelicolor | butyl pentanoate + ? | - |
? | |
| S-(2-acetamidoethyl) ethanethioate + hexanol | - |
Streptomyces coelicolor | hexyl acetate + ? | - |
? | |
| S-(2-acetamidoethyl) pentanethioate + butanol | - |
Streptomyces coelicolor | butyl 2,2-dimethylpropanoate + ? | - |
? | |
| S-(2-acetamidoethyl) pentanethioate + hexanol | - |
Streptomyces coelicolor | hexyl pentanoate + ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 47000, His6-tagged recombinant enzyme, SDS-PAGE | Streptomyces coelicolor |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| wax synthase | - |
Streptomyces coelicolor |
| WS-SCo | recombinant enzyme | Streptomyces coelicolor |
| WS/DGAT | - |
Streptomyces coelicolor |
kcat/KM [mM/s]
| kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.04 | - |
acetyl-CoA | pH and temperature not specified in the publication | Streptomyces coelicolor | |
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