Literature summary for 2.3.1.75 extracted from

Yang, T.; Li, Y.; Liu, Y.; He, L.; Liu, A.; Wen, J.; Mysore, K.S.; Tadege, M.; Chen, J.
The 3-ketoacyl-CoA synthase WFL is involved in lateral organ development and cuticular wax synthesis in Medicago truncatula (2021), Plant Mol. Biol., 105, 193-204.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
acyl-CoA + a long-chain alcohol	Medicago truncatula	-	CoA + a long-chain ester	-	?

Organism

Organism	UniProt	Comment	Textmining
Medicago truncatula	-	ecotype R108	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
carpel	high expression	Medicago truncatula	-
epidermal cell	-	Medicago truncatula	-
leaf	-	Medicago truncatula	-
petal	highest expression	Medicago truncatula	-
root	lowest expression	Medicago truncatula	-
shoot	high expression in vegetative and reproductive shoot	Medicago truncatula	-
shoot apical meristem	-	Medicago truncatula	-
stamen	high expression	Medicago truncatula	-
stem	-	Medicago truncatula	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acyl-CoA + a long-chain alcohol	-	Medicago truncatula	CoA + a long-chain ester	-	?

Synonyms

Synonyms	Comment	Organism
3-ketoacyl-CoA synthase	-	Medicago truncatula
KCS	-	Medicago truncatula
Medtr3g105550	-	Medicago truncatula
WFL	-	Medicago truncatula

General Information

General Information	Comment	Organism
malfunction	the wfl gene mutants (wrinkled flower and leaf) show sparse epicuticular wax crystals on the leaf surface and increased water permeability in leaves compared to the wild type. The mutation of the enzyme leads to a markedly increased percentage of C20:0, C22:0, and C24:0 fatty acids in leaves, a significantly reduced cuticular wax content, and dramatic changes of wax constituents in leaves	Medicago truncatula
physiological function	the enzyme plays a key role in very long chain fatty acid biosynthesis, cuticular wax formation and in the late stage of leaf and flower development	Medicago truncatula

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Release 2026.1 (March 2026)