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Literature summary for 2.3.1.75 extracted from

  • Widjaja-Adhi, M.A.K.; Kolesnikov, A.V.; Vasudevan, S.; Park, P.S.; Kefalov, V.J.; Golczak, M.
    Acyl-CoA wax alcohol acyltransferase 2 modulates the cone visual cycle in mouse retina (2022), FASEB J., 36, e22390.
    View publication on PubMed
Search for more literature for 2.3.1.75

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acyl-CoA + a long-chain alcohol Mus musculus
-
 CoA + a long-chain ester
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q6E1M8
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Mueller cell
-
 Mus musculus
-
retina
-
 Mus musculus
-
retinal pigment epithelium
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-CoA + a long-chain alcohol
-
 Mus musculus CoA + a long-chain ester
-
 ?
myristoyl-CoA + 11-cis-retinal
-
 Mus musculus 11-cis-retinyl myristate + CoA
-
 ?
myristoyl-CoA + all-trans-retinal
-
 Mus musculus all-trans-retinyl myristate + CoA
-
 ?

Synonyms

Synonyms Comment Organism
acyl-CoA wax alcohol acyltransferase 2
-
 Mus musculus
acyl-CoA:wax alcohol acyltransferase 2
-
 Mus musculus
AWAT2
-
 Mus musculus
MFAT
-
 Mus musculus
multifunctional O-acyltransferase
-
 Mus musculus

General Information

General Information Comment Organism
malfunction the global absence of AWAT2 enzymatic activity does not affect gross retinal morphology or the rate of visual chromophore regeneration by the canonical retinal pigment epithelium-specific 65 kDa protein-dependent visual cycle. There are reduced maximal rod and cone dark-adapted responses in enzyme-deficient mice compared to control mice. While rod dark adaptation is not affected by the lack of enzyme, M-cone dark adaptation both in isolated retina and in vivo is significantly suppressed Mus musculus
physiological function the enzyme is not required for the normal operation of the canonical visual cycle, but it is a functional component of the cone-specific visual chromophore regenerative pathway Mus musculus