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Literature summary for 2.3.1.74 extracted from

  • Pandith, S.A.; Ramazan, S.; Khan, M.I.; Reshi, Z.A.; Shah, M.A.
    Chalcone synthases (CHSs) the symbolic type III polyketide synthases (2019), Planta, 251, 15 .
    View publication on PubMed
Search for more literature for 2.3.1.74

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Rheum australe 5737
-
nucleus
-
 Rheum australe 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3 malonyl-CoA + 4-coumaroyl-CoA Rheum australe 100% activity 4 CoA + naringenin chalcone + 3 CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Rheum australe A0A096X8J8
-
-
Rheum australe A0A0A0P7Q3
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2RS)-methylmalonyl-CoA + n-hexanoyl-CoA
-
 Rheum australe triketide lactone + 6-ethyl-4-hydroxy-3,5-dimethyl-2-pyrone
-
 ?
3 malonyl-CoA + 4-coumaroyl-CoA 100% activity Rheum australe 4 CoA + naringenin chalcone + 3 CO2
-
 ?
4-coumaroyl-CoA + (2RS)-methylmalonyl-CoA
-
 Rheum australe 1-(4-hydroxyphenyl)pent-1-en-3-one
-
 ?
cinnamoyl diketide-NAC + (2RS)-methylmalonyl-CoA
-
 Rheum australe methylated triketide styrylpyrone + ?
-
 ?
malonyl-CoA + 4-fluorocinnamoyl-CoA
-
 Rheum australe fluorinated chalcone + alpha-pyrone + 2 CoA
-
 ?
malonyl-CoA + acetyl-CoA isoform CHS1 exhibits 21.15% activity compared to 4-coumaryl-CoA Rheum australe ?
-
 ?
malonyl-CoA + acetyl-CoA isoform CHS2 exhibits 138.11% activity compared to 4-coumaryl-CoA Rheum australe ?
-
 ?
malonyl-CoA + benzoyl-CoA
-
 Rheum australe bis-noryangonin + 4-coumaroyl triacetic acid lactone + CoA + CO2
-
 ?
malonyl-CoA + butyryl-CoA isoform CHS1 exhibits 18.85% activity compared to 4-coumaryl-CoA Rheum australe ?
-
 ?
malonyl-CoA + butyryl-CoA isoform CHS2 exhibits 45.38% activity compared to 4-coumaryl-CoA Rheum australe ?
-
 ?
malonyl-CoA + hexanoyl-CoA isoform CHS1 exhibits 3.09% activity compared to 4-coumaryl-CoA Rheum australe ?
-
 ?
malonyl-CoA + hexanoyl-CoA isoform CHS2 exhibits 2.36% activity compared to 4-coumaryl-CoA Rheum australe ?
-
 ?
malonyl-CoA + octanoyl-CoA isoform CHS1 exhibits 22.04% activity compared to 4-coumaryl-CoA Rheum australe ?
-
 ?
malonyl-CoA + octanoyl-CoA isoform CHS2 exhibits 72.39% activity compared to 4-coumaryl-CoA Rheum australe ?
-
 ?
methylmalonyl-CoA + benzoyl-CoA
-
 Rheum australe triketide alpha-pyrone + tetraketide alpha-pyrone
-
 ?
n-hexanoyl-CoA + butyryl-CoA
-
 Rheum australe phlorobutyrophenone + phlorocaprophenone
-
 ?

Subunits

Subunits Comment Organism
homodimer 2 * about 43230, calculated from amino acid sequence Rheum australe

Synonyms

Synonyms Comment Organism
Chs1 isoform Rheum australe
Chs2 isoform Rheum australe

pI Value

Organism Comment pI Value Maximum pI Value
Rheum australe calculated from amino acid sequence
-
 6

General Information

General Information Comment Organism
metabolism the enzyme catalyzes the initial step of the phenylpropanoid pathway Rheum australe

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
10
-
 hexanoyl-CoA isoform CHS1, pH and temperature not specified in the publication Rheum australe
30
-
 octanoyl-CoA isoform CHS1, pH and temperature not specified in the publication Rheum australe
50
-
 acetyl-CoA isoform CHS1, pH and temperature not specified in the publication Rheum australe
50
-
 butyryl-CoA isoform CHS1, pH and temperature not specified in the publication Rheum australe
170
-
 4-coumaroyl-CoA isoform CHS2, pH and temperature not specified in the publication Rheum australe
300
-
 hexanoyl-CoA isoform CHS2, pH and temperature not specified in the publication Rheum australe
580
-
 octanoyl-CoA isoform CHS2, pH and temperature not specified in the publication Rheum australe
787
-
 4-coumaroyl-CoA isoform CHS1, pH and temperature not specified in the publication Rheum australe
990
-
 butyryl-CoA isoform CHS2, pH and temperature not specified in the publication Rheum australe
1240
-
 acetyl-CoA isoform CHS2, pH and temperature not specified in the publication Rheum australe