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Literature summary for 2.3.1.74 extracted from
- Reaction mechanisms of homodimeric plant polyketide synthases (stilbene and chalcone synthase). A single active site for the condensing reaction is sufficient for synthesis of stilbenes, chalcones, and 6'-deoxychalcones (1995), J. Biol. Chem., 270, 7922-7928.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Sinapis alba |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| C169S | no enzyme activity | Sinapis alba |
| C169S/Q100E | 28% of wild-type activity | Sinapis alba |
| C169S/Q100E/K180Q | 15% of wild-type activity | Sinapis alba |
| K180Q | no enzyme activity | Sinapis alba |
| Q100E | 14% of wild-type activity | Sinapis alba |
| S158C | 90% of wild-type activity | Sinapis alba |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0023 | - |
4-coumaroyl-CoA | C169S/Q100E/K180Q triple mutant | Sinapis alba |  |
| 0.0025 | - |
4-coumaroyl-CoA | wild-type enzyme | Sinapis alba | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sinapis alba | - |
white mustard | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| malonyl CoA + 4-coumaroyl-CoA + NADH | - |
Sinapis alba | 6'-deoxychalcone + CoA + CO2 + NAD+ | the formation of this product requires an additional reductase | ? | |
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