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Literature summary for 2.3.1.74 extracted from
- Evidence for catalytic cysteine-histidine dyad in chalcone synthase (2000), Biochem. Biophys. Res. Commun., 275, 725-730.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| wild type and mutants | Pueraria montana var. lobata |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| C164S | inhibition by diethyl diphosphate is pH dependent | Pueraria montana var. lobata |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| diethyl diphosphate | inhibition of wild-type enzyme is pH independent, inhibition of C164S mutant increases with increasing pH between pH 6.2 to pH 7.4 | Pueraria montana var. lobata |  |
| iodoacetamide | due to labeling of C164 | Pueraria montana var. lobata | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Pueraria montana var. lobata | - |
- |
- |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Pueraria montana var. lobata |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| malonyl CoA + 4-coumaroyl-CoA + NADH | - |
Pueraria montana var. lobata | 6'-deoxychalcone + CoA + CO2 + NAD+ | - |
? | |
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