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Literature summary for 2.3.1.7 extracted from

  • Jaudzems, K.; Kuka, J.; Gutsaits, A.; Zinovjevs, K.; Kalvinsh, I.; Liepinsh, E.; Liepinsh, E.; Dambrova, M.
    Inhibition of carnitine acetyltransferase by mildronate, a regulator of energy metabolism (2009), J. Enzyme Inhib. Med. Chem., 24, 1269-1275.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
3-(2,2,2-trimethylhydrazinium)-propionate mildronate, competitive (binding to the carnitine binding site) Columba livia

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.395
-
carnitine
-
Columba livia

Organism

Organism UniProt Comment Textmining
Columba livia
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
muscle breast muscle Columba livia
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + carnitine
-
Columba livia CoA + acetylcarnitine
-
r

Synonyms

Synonyms Comment Organism
carnitine acetyltransferase
-
Columba livia

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.6
-
3-(2,2,2-trimethylhydrazinium)-propionate 0.0625 mM carnitine Columba livia

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.44
-
0.0625 mM carnitine Columba livia 3-(2,2,2-trimethylhydrazinium)-propionate