Literature summary for 2.3.1.7 extracted from

Fritz, I.B.; Schultz, S.K.
Carnitine acetyltransferase. II. Inhibition by carnitine analogues and by sulfhydryl reagents (1965), J. Biol. Chem., 240, 2188-2192.

Search for more literature for 2.3.1.7

Inhibitors

Inhibitors	Comment	Organism	Structure
(+)-acetylcarnitine	competitive inhibition	Sus scrofa
(+)-carnitine	-	Sus scrofa
(-)-acetylcarnitine	noncompetitive inhibition	Sus scrofa
5,5'-dithio-bis(2-nitrobenzoic acid)	-	Sus scrofa
acetylcarnitine	-	Sus scrofa
carnitine nitrile	-	Sus scrofa
choline	-	Sus scrofa
deoxycarnitine	competitive inhibition	Sus scrofa
DL-acetyl-beta-methylcholine	-	Sus scrofa
DL-acetylcarnitine	competitive inhibition	Sus scrofa
DL-carnitine	-	Sus scrofa
gamma-aminobutyrate	-	Sus scrofa
HgCl2	-	Sus scrofa
iodoacetamide	-	Sus scrofa
N-ethylmaleimide	-	Sus scrofa
p-hydroxymercuribenzoate	-	Sus scrofa
Prostigmine	-	Sus scrofa
tensilon	-	Sus scrofa

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.041	-	CoASH	-	Sus scrofa
0.31	-	(-)carnitine	-	Sus scrofa
1.6	-	(-)-norcarnitine	-	Sus scrofa
3.2	-	DL-norcarnitine	-	Sus scrofa
40	-	DL-beta-hydroxy-gamma-aminobutyrate	-	Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
acetyl-CoA + carnitine	Sus scrofa	-	O-acetylcarnitine + CoASH	-	r
acyl-CoA + carnitine	Sus scrofa	-	acylcarnitine + CoASH	-	r
acylcarnitine + CoASH	Sus scrofa	-	acyl-CoA + carnitine	-	r
O-acetylcarnitine + CoASH	Sus scrofa	-	acetyl-CoA + carnitine	-	r

Organism

Organism	UniProt	Comment	Textmining
Sus scrofa	-	pig	-

Purification (Commentary)

Purification (Comment)	Organism
partially	Sus scrofa

Source Tissue

Source Tissue	Comment	Organism	Textmining
heart	-	Sus scrofa	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-CoA + (-)-norcarnitine	beta-hydroxy-gamma-dimethylaminobutyrate	Sus scrofa	acetylnorcarnitine + CoASH	-	r
acetyl-CoA + carnitine	-	Sus scrofa	O-acetylcarnitine + CoASH	-	r
acetyl-CoA + DL-beta-hydroxy-gamma-aminobutyrate	non-methylated derivative of carnitine	Sus scrofa	beta-hydroxybutyrate + CoASH	-	r
acetyl-CoA + DL-norcarnitine	beta-hydroxy-gamma-dimethylaminobutyrate	Sus scrofa	acetylnorcarnitine + CoASH	-	r
acetyl-CoA + L-(-)carnitine	-	Sus scrofa	O-acetylcarnitine + CoASH	-	r
acyl-CoA + carnitine	-	Sus scrofa	acylcarnitine + CoASH	-	r
acylcarnitine + CoASH	-	Sus scrofa	acyl-CoA + carnitine	-	r
additional information	only (-) optical isomers are substrates, unnatural (+) isomers are competitive inhibitors	Sus scrofa	?	-	?
O-acetylcarnitine + CoASH	-	Sus scrofa	acetyl-CoA + L-(-)carnitine	-	r
O-acetylcarnitine + CoASH	-	Sus scrofa	acetyl-CoA + carnitine	-	r

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.25	-	(+)-acetylcarnitine	-	Sus scrofa
0.39	-	DL-acetylcarnitine	-	Sus scrofa
0.62	-	DL-carnitine	-	Sus scrofa
1.2	-	deoxynorcarnitine	-	Sus scrofa
2.1	-	(+)carnitine	-	Sus scrofa
2.3	-	deoxycarnitine	-	Sus scrofa
12	-	Prostigmine	-	Sus scrofa
15	-	tensilon	-	Sus scrofa
27	-	choline	-	Sus scrofa
44	-	gamma-aminobutyrate	-	Sus scrofa
71	-	DL-acetyl-beta-methylcholine	-	Sus scrofa

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Release 2023.1 (January 2023)